Association study indicates a protective role of phosphatidylinositol-4-phosphate-5-kinase against tardive dyskinesia

Olga Yu Fedorenko, Anton J.M. Loonen, Florian Lang, Valentina A. Toshchakova, Evgenia G. Boyarko, Arkadiy V. Semke, Nikolay A. Bokhan, Nikolay V. Govorin, Lyubomir I. Aftanas, Svetlana A. Ivanova

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: Tardive dyskinesia is a disorder characterized by involuntary muscle movements that occur as a complication of long-term treatment with antipsychotic drugs. It has been suggested to be related to a malfunctioning of the indirect pathway of the motor part of the cortical-striatal-thalamic-cortical circuit, which may be caused by oxidative stress-induced neurotoxicity. Methods: The purpose of our study was to investigate the possible association between phosphatidylinositol-4-phosphate-5-kinase type IIa (PIP5K2A) function and tardive dyskinesia in 491 Caucasian patients with schizophrenia from 3 different psychiatric institutes in West Siberia. The Abnormal Involuntary Movement Scale was used to assess tardive dyskinesia. Individuals were genotyped for 3 single nucleotide polymorphisms in PIP5K2A gene: rs10828317, rs746203, and rs8341. Results: A significant association was established between the functional mutation N251S-polymorphism of the PIP5K2A gene (rs10828317) and tardive dyskinesia, while the other 2 examined nonfunctional single nucleotide polymorphisms were not related. Conclusions: We conclude from this association that PIP5K2A is possibly involved in a mechanism protecting against tardive dyskinesia-inducing neurotoxicity. This corresponds to our hypothesis that tardive dyskinesia is related to neurotoxicity at striatal indirect pathway medium-sized spiny neurons.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalInternational Journal of Neuropsychopharmacology
Volume18
Issue number6
DOIs
Publication statusPublished - 1 Jan 2015

Fingerprint

Corpus Striatum
Single Nucleotide Polymorphism
Siberia
Efferent Pathways
Dyskinesias
Antipsychotic Agents
Genes
Smooth Muscle
Psychiatry
1-phosphatidylinositol-4-phosphate 5-kinase
Tardive Dyskinesia
Schizophrenia
Oxidative Stress
Neurons
Mutation
Therapeutics
Abnormal Involuntary Movement Scale

Keywords

  • gene polymorphism
  • medium spiny neurons
  • neurotoxicity
  • PIP5K2A
  • schizophrenia
  • tardive dyskinesia

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)

Cite this

Association study indicates a protective role of phosphatidylinositol-4-phosphate-5-kinase against tardive dyskinesia. / Fedorenko, Olga Yu; Loonen, Anton J.M.; Lang, Florian; Toshchakova, Valentina A.; Boyarko, Evgenia G.; Semke, Arkadiy V.; Bokhan, Nikolay A.; Govorin, Nikolay V.; Aftanas, Lyubomir I.; Ivanova, Svetlana A.

In: International Journal of Neuropsychopharmacology, Vol. 18, No. 6, 01.01.2015, p. 1-6.

Research output: Contribution to journalArticle

Fedorenko, Olga Yu ; Loonen, Anton J.M. ; Lang, Florian ; Toshchakova, Valentina A. ; Boyarko, Evgenia G. ; Semke, Arkadiy V. ; Bokhan, Nikolay A. ; Govorin, Nikolay V. ; Aftanas, Lyubomir I. ; Ivanova, Svetlana A. / Association study indicates a protective role of phosphatidylinositol-4-phosphate-5-kinase against tardive dyskinesia. In: International Journal of Neuropsychopharmacology. 2015 ; Vol. 18, No. 6. pp. 1-6.
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AU - Boyarko, Evgenia G.

AU - Semke, Arkadiy V.

AU - Bokhan, Nikolay A.

AU - Govorin, Nikolay V.

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