Association study indicates a protective role of phosphatidylinositol-4-phosphate-5-kinase against tardive dyskinesia

Olga Yu Fedorenko, Anton J.M. Loonen, Florian Lang, Valentina A. Toshchakova, Evgenia G. Boyarko, Arkadiy V. Semke, Nikolay A. Bokhan, Nikolay V. Govorin, Lyubomir I. Aftanas, Svetlana A. Ivanova

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)


Background: Tardive dyskinesia is a disorder characterized by involuntary muscle movements that occur as a complication of long-term treatment with antipsychotic drugs. It has been suggested to be related to a malfunctioning of the indirect pathway of the motor part of the cortical-striatal-thalamic-cortical circuit, which may be caused by oxidative stress-induced neurotoxicity. Methods: The purpose of our study was to investigate the possible association between phosphatidylinositol-4-phosphate-5-kinase type IIa (PIP5K2A) function and tardive dyskinesia in 491 Caucasian patients with schizophrenia from 3 different psychiatric institutes in West Siberia. The Abnormal Involuntary Movement Scale was used to assess tardive dyskinesia. Individuals were genotyped for 3 single nucleotide polymorphisms in PIP5K2A gene: rs10828317, rs746203, and rs8341. Results: A significant association was established between the functional mutation N251S-polymorphism of the PIP5K2A gene (rs10828317) and tardive dyskinesia, while the other 2 examined nonfunctional single nucleotide polymorphisms were not related. Conclusions: We conclude from this association that PIP5K2A is possibly involved in a mechanism protecting against tardive dyskinesia-inducing neurotoxicity. This corresponds to our hypothesis that tardive dyskinesia is related to neurotoxicity at striatal indirect pathway medium-sized spiny neurons.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalInternational Journal of Neuropsychopharmacology
Issue number6
Publication statusPublished - 1 Jan 2015


  • gene polymorphism
  • medium spiny neurons
  • neurotoxicity
  • PIP5K2A
  • schizophrenia
  • tardive dyskinesia

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)

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