Abstract
Objective. To study the association between polymorphisms of PIP5K2A and HTR2C genes and response to antidepressant therapy in patients with a current depressive episode. Material and methods. The study included 222 patients (168 women and 54 men) with a current depressive episode. The assessment of the severity of the current depressive episode and the efficacy of treatment was performed using the Hamilton depression scale (HDRS-17) and the Clinical global impression scale (CGI-S, CGI-I). The association of treatment efficacy with PIP5K2A polymorphisms rs10430590, rs10828317 and HTR2C polymorphisms rs6318, rs569959, rs3813929, rs12858300 was studied. Results and conclusion. Polymorphisms rs10828317 and rs10430590 in the PIP5K2A gene were associated with the CGI-S total score at day 28 of therapy. Polymorphism rs6318 in the HTR2C gene was associated with response to antidepressant therapy followed by clinical improvement of patients with current depressive episode on the 28th day of antidepressant therapy.
| Original language | English |
|---|---|
| Pages (from-to) | 58-61 |
| Number of pages | 4 |
| Journal | Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova |
| Volume | 117 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 1 Jan 2017 |
| Externally published | Yes |
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Keywords
- Depressive episode
- Gene polymorphism
- HTR2C
- PIP5K2A
- Treatment efficacy
ASJC Scopus subject areas
- Clinical Neurology
- Psychiatry and Mental health
Cite this
Association of polymorphic variants of PIP5K2A and HTR2C genes with response to antidepressant therapy of patients with a current depressive episode. / Vyalova, N. M.; Pozhidaev, I. V.; Osmanova, D. Z.; Simutkin, G. G.; Ivanova, S. A.; Bokhan, N. A.
In: Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova, Vol. 117, No. 5, 01.01.2017, p. 58-61.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Association of polymorphic variants of PIP5K2A and HTR2C genes with response to antidepressant therapy of patients with a current depressive episode
AU - Vyalova, N. M.
AU - Pozhidaev, I. V.
AU - Osmanova, D. Z.
AU - Simutkin, G. G.
AU - Ivanova, S. A.
AU - Bokhan, N. A.
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Objective. To study the association between polymorphisms of PIP5K2A and HTR2C genes and response to antidepressant therapy in patients with a current depressive episode. Material and methods. The study included 222 patients (168 women and 54 men) with a current depressive episode. The assessment of the severity of the current depressive episode and the efficacy of treatment was performed using the Hamilton depression scale (HDRS-17) and the Clinical global impression scale (CGI-S, CGI-I). The association of treatment efficacy with PIP5K2A polymorphisms rs10430590, rs10828317 and HTR2C polymorphisms rs6318, rs569959, rs3813929, rs12858300 was studied. Results and conclusion. Polymorphisms rs10828317 and rs10430590 in the PIP5K2A gene were associated with the CGI-S total score at day 28 of therapy. Polymorphism rs6318 in the HTR2C gene was associated with response to antidepressant therapy followed by clinical improvement of patients with current depressive episode on the 28th day of antidepressant therapy.
AB - Objective. To study the association between polymorphisms of PIP5K2A and HTR2C genes and response to antidepressant therapy in patients with a current depressive episode. Material and methods. The study included 222 patients (168 women and 54 men) with a current depressive episode. The assessment of the severity of the current depressive episode and the efficacy of treatment was performed using the Hamilton depression scale (HDRS-17) and the Clinical global impression scale (CGI-S, CGI-I). The association of treatment efficacy with PIP5K2A polymorphisms rs10430590, rs10828317 and HTR2C polymorphisms rs6318, rs569959, rs3813929, rs12858300 was studied. Results and conclusion. Polymorphisms rs10828317 and rs10430590 in the PIP5K2A gene were associated with the CGI-S total score at day 28 of therapy. Polymorphism rs6318 in the HTR2C gene was associated with response to antidepressant therapy followed by clinical improvement of patients with current depressive episode on the 28th day of antidepressant therapy.
KW - Depressive episode
KW - Gene polymorphism
KW - HTR2C
KW - PIP5K2A
KW - Treatment efficacy
UR - http://www.scopus.com/inward/record.url?scp=85021966953&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85021966953&partnerID=8YFLogxK
U2 - 10.17116/jnevro20171175158-61
DO - 10.17116/jnevro20171175158-61
M3 - Article
VL - 117
SP - 58
EP - 61
JO - Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova
JF - Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova
SN - 0044-4588
IS - 5
ER -