Abstract
A simple, convenient, and environment-friendly procedure for the preparation of substituted biaryls via Suzuki-Miyaura cross-coupling was developed. The use of arenediazonium tosylates and corresponding boron compounds allows a conversion in neat water in the presence of commercially available Pd(OAc)2 under mild conditions with tolerance to a wide range of functional groups. A procedure particularly useful for the synthesis of di-ortho-substituted biaryls was developed.
Original language | English |
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Article number | ss-2016-z0633-op |
Pages (from-to) | 1680-1688 |
Number of pages | 9 |
Journal | Synthesis (Germany) |
Volume | 49 |
Issue number | 7 |
DOIs | |
Publication status | Published - 1 Apr 2017 |
Keywords
- arenediazonium salts
- arenediazonium tosylates
- biphenyls
- Suzuki-Miyaura reactions
- water media
ASJC Scopus subject areas
- Catalysis
- Organic Chemistry