Arenediazonium Tosylates (ADTs) as Efficient Reagents for Suzuki-Miyaura Cross-Coupling in Neat Water

Ksenia V. Kutonova, Nicole Jung, Marina E. Trusova, Victor D. Filimonov, Pavel S. Postnikov, Stefan Bräse

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

A simple, convenient, and environment-friendly procedure for the preparation of substituted biaryls via Suzuki-Miyaura cross-coupling­ was developed. The use of arenediazonium tosylates and corresponding boron compounds allows a conversion in neat water in the presence of commercially available Pd(OAc)2 under mild conditions with tolerance to a wide range of functional groups. A procedure particularly useful for the synthesis of di-ortho-substituted biaryls was developed.

Original languageEnglish
Article numberss-2016-z0633-op
Pages (from-to)1680-1688
Number of pages9
JournalSynthesis (Germany)
Volume49
Issue number7
DOIs
Publication statusPublished - 1 Apr 2017

Keywords

  • arenediazonium salts
  • arenediazonium tosylates
  • biphenyls
  • Suzuki-Miyaura reactions
  • water media

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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