Arenediazonium Tosylates (ADTs) as Efficient Reagents for Suzuki-Miyaura Cross-Coupling in Neat Water

Abstract

A simple, convenient, and environment-friendly procedure for the preparation of substituted biaryls via Suzuki-Miyaura cross-coupling was developed. The use of arenediazonium tosylates and corresponding boron compounds allows a conversion in neat water in the presence of commercially available Pd(OAc)₂ under mild conditions with tolerance to a wide range of functional groups. A procedure particularly useful for the synthesis of di-ortho-substituted biaryls was developed.

Original language	English
Article number	ss-2016-z0633-op
Pages (from-to)	1680-1688
Number of pages	9
Journal	Synthesis (Germany)
Volume	49
Issue number	7
DOIs	https://doi.org/10.1055/s-0036-1588919
Publication status	Published - 1 Apr 2017

Keywords

arenediazonium salts
arenediazonium tosylates
biphenyls
Suzuki-Miyaura reactions
water media

ASJC Scopus subject areas

Catalysis
Organic Chemistry

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10.1055/s-0036-1588919

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Arenediazonium Tosylates (ADTs) as Efficient Reagents for Suzuki-Miyaura Cross-Coupling in Neat Water. / Kutonova, Ksenia V.; Jung, Nicole; Trusova, Marina E.; Filimonov, Victor D.; Postnikov, Pavel S.; Bräse, Stefan.

In: Synthesis (Germany), Vol. 49, No. 7, ss-2016-z0633-op, 01.04.2017, p. 1680-1688.

Research output: Contribution to journal › Article › peer-review

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AU - Filimonov, Victor D.

AU - Postnikov, Pavel S.

AU - Bräse, Stefan

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KW - Suzuki-Miyaura reactions

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