Applications of Smart Multifunctional Tissue Engineering Scaffolds

M. Kaliva, M. Chatzinikolaidou, M. Vamvakaki

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Citations (Scopus)


Tissue engineering is a modern interdisciplinary field based on the principles of biology and engineering that has emerged as a therapeutic strategy aiming to replace lost or damaged tissues and organs in patients. The field combines knowledge and developments from the research areas of materials science, stem cells and developmental biology (growth and differentiation factors) with engineering. Current challenges in this area include the demand for multifunctional and mechanically robust three-dimensional (3-D) structures, the availability of the appropriate type of stem cells as well as the replication of the specific physiological environment during culture. Biomaterials constitute an essential component of tissue engineering. They are used to construct scaffolds that mimic the extracellular matrix in supporting tissue regeneration and ideally degrade at the same rate as that of the tissue growth. Both natural and synthetic biomaterials, polymers and ceramics, have been investigated in the fabrication of scaffolds, whereas lately hybrid organic-inorganic materials have attracted particular attention. The characteristics and importance of the multifunctionality and smart behavior of the biomaterials and scaffolds, in performing more than one action, during in vitro and in vivo tissue regeneration in specific applications are highlighted in this chapter.

Original languageEnglish
Title of host publicationSelf-Cleaning Coatings
Subtitle of host publicationStructure, Fabrication and Application
EditorsQun Wang
PublisherRoyal Society of Chemistry
Number of pages38
Publication statusPublished - 2017
Externally publishedYes

Publication series

NameRSC Smart Materials
ISSN (Print)2046-0066
ISSN (Electronic)2046-0074

ASJC Scopus subject areas

  • Biotechnology
  • Biomedical Engineering
  • Materials Science(all)
  • Energy Engineering and Power Technology
  • Electrical and Electronic Engineering

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