Applications of iodonium salts and iodonium ylides as precursors for nucleophilic fluorination in positron emission tomography

Mekhman S. Yusubov, Dmitrii Yu Svitich, Mariia S. Larkina, Viktor Vladimirovich Zhdankin

Research output: Contribution to journalArticle

29 Citations (Scopus)


This review summarizes the applications of iodonium compounds in the rapidly developing field of Positron Emission Tomography (PET). Reactions of diaryliodonium salts with fluoride anion have found wide practical application in PET as a fast and convenient method for the introduction of the radioactive [18F]-fluoride into radiotracer molecules. The best synthetic methods for the preparation of iodonium precursors for PET are described, the mechanistic aspects of nucleophilic fluorination reaction are discussed, and specific examples of the preparation of PET radioligands are provided.

Original languageEnglish
Pages (from-to)364-395
Number of pages32
Issue number1
Publication statusPublished - 20 Jul 2013



  • Fluorine-18
  • Iodonium salts
  • Iodonium ylides
  • Nucleophilic fluorination
  • Pet

ASJC Scopus subject areas

  • Organic Chemistry

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