Abstract
This review summarizes the applications of iodonium compounds in the rapidly developing field of Positron Emission Tomography (PET). Reactions of diaryliodonium salts with fluoride anion have found wide practical application in PET as a fast and convenient method for the introduction of the radioactive [18F]-fluoride into radiotracer molecules. The best synthetic methods for the preparation of iodonium precursors for PET are described, the mechanistic aspects of nucleophilic fluorination reaction are discussed, and specific examples of the preparation of PET radioligands are provided.
| Original language | English |
|---|---|
| Pages (from-to) | 364-395 |
| Number of pages | 32 |
| Journal | Arkivoc |
| Volume | 2013 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 20 Jul 2013 |
Keywords
- Fluorine-18
- Iodonium salts
- Iodonium ylides
- Nucleophilic fluorination
- Pet
ASJC Scopus subject areas
- Organic Chemistry
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Yusubov, M. S., Svitich, D. Y., Larkina, M. S., & Zhdankin, V. V. (2013). Applications of iodonium salts and iodonium ylides as precursors for nucleophilic fluorination in positron emission tomography. Arkivoc, 2013(1), 364-395. https://doi.org/10.3998/ark.5550190.p008.225