Applications of iodonium salts and iodonium ylides as precursors for nucleophilic fluorination in positron emission tomography

Mekhman S. Yusubov, Dmitrii Yu Svitich, Mariia S. Larkina, Viktor Vladimirovich Zhdankin

Research School of Chemistry & Applied Biomedical Sciences

Research output: Contribution to journal › Article

Abstract

This review summarizes the applications of iodonium compounds in the rapidly developing field of Positron Emission Tomography (PET). Reactions of diaryliodonium salts with fluoride anion have found wide practical application in PET as a fast and convenient method for the introduction of the radioactive [18F]-fluoride into radiotracer molecules. The best synthetic methods for the preparation of iodonium precursors for PET are described, the mechanistic aspects of nucleophilic fluorination reaction are discussed, and specific examples of the preparation of PET radioligands are provided.

Original language	English
Pages (from-to)	364-395
Number of pages	32
Journal	Arkivoc
Volume	2013
Issue number	1
DOIs	https://doi.org/10.3998/ark.5550190.p008.225
Publication status	Published - 20 Jul 2013

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Keywords

Fluorine-18
Iodonium salts
Iodonium ylides
Nucleophilic fluorination
Pet

ASJC Scopus subject areas

Organic Chemistry

Cite this

Yusubov, M. S., Svitich, D. Y., Larkina, M. S., & Zhdankin, V. V. (2013). Applications of iodonium salts and iodonium ylides as precursors for nucleophilic fluorination in positron emission tomography. Arkivoc, 2013(1), 364-395. https://doi.org/10.3998/ark.5550190.p008.225

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10.3998/ark.5550190.p008.225