Application of non-stop-flow differential pulse voltammetry at a tubular detector of silver solid amalgam for electrochemical determination of lomustine (CCNU)

Oksana Josypčuk, Jiří Barek, Bohdan Josypčuk

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

An application of the flow differential pulse voltammetry with tubular detector based on silver solid amalgam for determination of antineoplastic drug lomustine in pharmaceutical preparations is presented. The highest sensitivity was obtained in [0.10moldm-3 MES; 2.00moldm-3 NaCl; pH6.0]:EtOH (9:1) with flow rate 0.50mLmin-1, and the magnitude of the modulation amplitude -0.070V. The calibration dependence was linear in the range 1×10-6-1×10-4moldm-3 (R2=0.999). The limit of detection was 1.5×10-7moldm-3. This method was successfully used for determination of lomustine in real samples of chemotherapy drug CeeNU Lomustine 40mg.

Original languageEnglish
Pages (from-to)306-311
Number of pages6
JournalElectroanalysis
Volume26
Issue number2
DOIs
Publication statusPublished - 1 Jan 2014
Externally publishedYes

Keywords

  • Chemotherapy drug
  • Flow systems
  • Lomustine
  • Silver solid amalgam
  • Tubular detector
  • Voltammetry

ASJC Scopus subject areas

  • Analytical Chemistry
  • Electrochemistry

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