Application of non-stop-flow differential pulse voltammetry at a tubular detector of silver solid amalgam for electrochemical determination of lomustine (CCNU)

Oksana Josypčuk, Jiří Barek, Bohdan Josypčuk

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

An application of the flow differential pulse voltammetry with tubular detector based on silver solid amalgam for determination of antineoplastic drug lomustine in pharmaceutical preparations is presented. The highest sensitivity was obtained in [0.10moldm-3 MES; 2.00moldm-3 NaCl; pH6.0]:EtOH (9:1) with flow rate 0.50mLmin-1, and the magnitude of the modulation amplitude -0.070V. The calibration dependence was linear in the range 1×10-6-1×10-4moldm-3 (R2=0.999). The limit of detection was 1.5×10-7moldm-3. This method was successfully used for determination of lomustine in real samples of chemotherapy drug CeeNU Lomustine 40mg.

Original languageEnglish
Pages (from-to)306-311
Number of pages6
JournalElectroanalysis
Volume26
Issue number2
DOIs
Publication statusPublished - 1 Jan 2014
Externally publishedYes

Fingerprint

Lomustine
Mercury amalgams
Chemotherapy
Amplitude modulation
Voltammetry
Silver
Drug products
Flow rate
Calibration
Detectors
Pharmaceutical Preparations
Antineoplastic Agents

Keywords

  • Chemotherapy drug
  • Flow systems
  • Lomustine
  • Silver solid amalgam
  • Tubular detector
  • Voltammetry

ASJC Scopus subject areas

  • Analytical Chemistry
  • Electrochemistry

Cite this

Application of non-stop-flow differential pulse voltammetry at a tubular detector of silver solid amalgam for electrochemical determination of lomustine (CCNU). / Josypčuk, Oksana; Barek, Jiří; Josypčuk, Bohdan.

In: Electroanalysis, Vol. 26, No. 2, 01.01.2014, p. 306-311.

Research output: Contribution to journalArticle

@article{505ee986cd5e4f249d91c2e7d5334186,
title = "Application of non-stop-flow differential pulse voltammetry at a tubular detector of silver solid amalgam for electrochemical determination of lomustine (CCNU)",
abstract = "An application of the flow differential pulse voltammetry with tubular detector based on silver solid amalgam for determination of antineoplastic drug lomustine in pharmaceutical preparations is presented. The highest sensitivity was obtained in [0.10moldm-3 MES; 2.00moldm-3 NaCl; pH6.0]:EtOH (9:1) with flow rate 0.50mLmin-1, and the magnitude of the modulation amplitude -0.070V. The calibration dependence was linear in the range 1×10-6-1×10-4moldm-3 (R2=0.999). The limit of detection was 1.5×10-7moldm-3. This method was successfully used for determination of lomustine in real samples of chemotherapy drug CeeNU Lomustine 40mg.",
keywords = "Chemotherapy drug, Flow systems, Lomustine, Silver solid amalgam, Tubular detector, Voltammetry",
author = "Oksana Josypčuk and Jiř{\'i} Barek and Bohdan Josypčuk",
year = "2014",
month = "1",
day = "1",
doi = "10.1002/elan.201300456",
language = "English",
volume = "26",
pages = "306--311",
journal = "Macromolecular Chemistry and Physics",
issn = "1040-0397",
publisher = "Wiley-VCH Verlag",
number = "2",

}

TY - JOUR

T1 - Application of non-stop-flow differential pulse voltammetry at a tubular detector of silver solid amalgam for electrochemical determination of lomustine (CCNU)

AU - Josypčuk, Oksana

AU - Barek, Jiří

AU - Josypčuk, Bohdan

PY - 2014/1/1

Y1 - 2014/1/1

N2 - An application of the flow differential pulse voltammetry with tubular detector based on silver solid amalgam for determination of antineoplastic drug lomustine in pharmaceutical preparations is presented. The highest sensitivity was obtained in [0.10moldm-3 MES; 2.00moldm-3 NaCl; pH6.0]:EtOH (9:1) with flow rate 0.50mLmin-1, and the magnitude of the modulation amplitude -0.070V. The calibration dependence was linear in the range 1×10-6-1×10-4moldm-3 (R2=0.999). The limit of detection was 1.5×10-7moldm-3. This method was successfully used for determination of lomustine in real samples of chemotherapy drug CeeNU Lomustine 40mg.

AB - An application of the flow differential pulse voltammetry with tubular detector based on silver solid amalgam for determination of antineoplastic drug lomustine in pharmaceutical preparations is presented. The highest sensitivity was obtained in [0.10moldm-3 MES; 2.00moldm-3 NaCl; pH6.0]:EtOH (9:1) with flow rate 0.50mLmin-1, and the magnitude of the modulation amplitude -0.070V. The calibration dependence was linear in the range 1×10-6-1×10-4moldm-3 (R2=0.999). The limit of detection was 1.5×10-7moldm-3. This method was successfully used for determination of lomustine in real samples of chemotherapy drug CeeNU Lomustine 40mg.

KW - Chemotherapy drug

KW - Flow systems

KW - Lomustine

KW - Silver solid amalgam

KW - Tubular detector

KW - Voltammetry

UR - http://www.scopus.com/inward/record.url?scp=84894341229&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84894341229&partnerID=8YFLogxK

U2 - 10.1002/elan.201300456

DO - 10.1002/elan.201300456

M3 - Article

VL - 26

SP - 306

EP - 311

JO - Macromolecular Chemistry and Physics

JF - Macromolecular Chemistry and Physics

SN - 1040-0397

IS - 2

ER -