Abstract
Guanidine containing polymers were applied to prepare polymer coated silica particles via a sol-gel method as potential candidates for drug encapsulation. Here, we used four types of grafted polymers for surface modification. The grafting amount was evaluated by thermogravimetric and elemental analysis and was in 18-34% range. Also polymer coated silica particles were characterized by Fourier transform infrared spectroscopy, differential scanning calorimetry and high resolution electron microscopy. The effect of grafted polymers on particle properties and pH-response has been reported. Anionic (sulfasalazine) and cationic (doxorubicin) drugs were effectively loaded into polymer coated silicas. The drug loading and drug release were pH dependent and affected by the nature of grafted polymer and its content. The properties revealed for investigated system have shown promising results for drug delivery with pH controllable drug release.
| Original language | English |
|---|---|
| Pages (from-to) | 26-34 |
| Number of pages | 9 |
| Journal | Colloids and Surfaces A: Physicochemical and Engineering Aspects |
| Volume | 477 |
| DOIs | |
| Publication status | Published - 1 Jul 2015 |
| Externally published | Yes |
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Keywords
- Doxorubicin
- Drug delivery
- Polymer coating
- Silica nanoparticles
- Sol-gel
- Sulfasalazine
ASJC Scopus subject areas
- Colloid and Surface Chemistry
Cite this
Application of guanidine-containing polymers for preparation of pH responsive silica-based particles for drug delivery systems. / Timin, Alexander S.; Balantseva, Elena V.; Khashirova, S. Yu; Rumyantsev, E. V.; Osadchaya, Tatiana Yu.
In: Colloids and Surfaces A: Physicochemical and Engineering Aspects, Vol. 477, 01.07.2015, p. 26-34.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Application of guanidine-containing polymers for preparation of pH responsive silica-based particles for drug delivery systems
AU - Timin, Alexander S.
AU - Balantseva, Elena V.
AU - Khashirova, S. Yu
AU - Rumyantsev, E. V.
AU - Osadchaya, Tatiana Yu
PY - 2015/7/1
Y1 - 2015/7/1
N2 - Guanidine containing polymers were applied to prepare polymer coated silica particles via a sol-gel method as potential candidates for drug encapsulation. Here, we used four types of grafted polymers for surface modification. The grafting amount was evaluated by thermogravimetric and elemental analysis and was in 18-34% range. Also polymer coated silica particles were characterized by Fourier transform infrared spectroscopy, differential scanning calorimetry and high resolution electron microscopy. The effect of grafted polymers on particle properties and pH-response has been reported. Anionic (sulfasalazine) and cationic (doxorubicin) drugs were effectively loaded into polymer coated silicas. The drug loading and drug release were pH dependent and affected by the nature of grafted polymer and its content. The properties revealed for investigated system have shown promising results for drug delivery with pH controllable drug release.
AB - Guanidine containing polymers were applied to prepare polymer coated silica particles via a sol-gel method as potential candidates for drug encapsulation. Here, we used four types of grafted polymers for surface modification. The grafting amount was evaluated by thermogravimetric and elemental analysis and was in 18-34% range. Also polymer coated silica particles were characterized by Fourier transform infrared spectroscopy, differential scanning calorimetry and high resolution electron microscopy. The effect of grafted polymers on particle properties and pH-response has been reported. Anionic (sulfasalazine) and cationic (doxorubicin) drugs were effectively loaded into polymer coated silicas. The drug loading and drug release were pH dependent and affected by the nature of grafted polymer and its content. The properties revealed for investigated system have shown promising results for drug delivery with pH controllable drug release.
KW - Doxorubicin
KW - Drug delivery
KW - Polymer coating
KW - Silica nanoparticles
KW - Sol-gel
KW - Sulfasalazine
UR - http://www.scopus.com/inward/record.url?scp=84927145276&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84927145276&partnerID=8YFLogxK
U2 - 10.1016/j.colsurfa.2015.03.037
DO - 10.1016/j.colsurfa.2015.03.037
M3 - Article
AN - SCOPUS:84927145276
VL - 477
SP - 26
EP - 34
JO - Colloids and Surfaces A: Physicochemical and Engineering Aspects
JF - Colloids and Surfaces A: Physicochemical and Engineering Aspects
SN - 0927-7757
ER -