Antiviral activity of Bacillus intermedius RNAase in guinea-pigs and rabbits infected with outdoor rabies virus

S. V. Gribencha, L. A. Potseluyeva, I. F. Barinsky, S. M. Deyev, T. G. Balandin, I. B. Leshchinskaya

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Single injection of Bacillus intermedius RNAase in a dose of 5 mg/kg could protect 40 and 50-70% of the outdoor rabies virus-preinfected guinea-pigs and rabbits, respectively. In the control group there were 100 and 75-100% deaths of the RNAase-untreated guinea-pigs and rabbits, respectively. Animal protection was observed only when RNAase was injected into the site of viral administration. The Intramuscular injection of RNAase, other than the site of viral administration failed to protect the infected animals, the efficacy (75%) of RNAase Injected into the rabbits was similar 1 and 24 hours after animal infection.

Original languageEnglish
Pages (from-to)41-43
Number of pages3
JournalVoprosy Virusologii
Volume51
Issue number5
Publication statusPublished - 2006

Keywords

  • Animal protection
  • Bacillus intermedius RNAase
  • Guinea-pigs
  • Outdoor rabies virus
  • Rabbits

ASJC Scopus subject areas

  • Virology

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  • Cite this

    Gribencha, S. V., Potseluyeva, L. A., Barinsky, I. F., Deyev, S. M., Balandin, T. G., & Leshchinskaya, I. B. (2006). Antiviral activity of Bacillus intermedius RNAase in guinea-pigs and rabbits infected with outdoor rabies virus. Voprosy Virusologii, 51(5), 41-43.