Antiviral activity of Bacillus intermedius RNAase in guinea-pigs and rabbits infected with outdoor rabies virus

S. V. Gribencha, L. A. Potseluyeva, I. F. Barinsky, S. M. Deyev, T. G. Balandin, I. B. Leshchinskaya

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Single injection of Bacillus intermedius RNAase in a dose of 5 mg/kg could protect 40 and 50-70% of the outdoor rabies virus-preinfected guinea-pigs and rabbits, respectively. In the control group there were 100 and 75-100% deaths of the RNAase-untreated guinea-pigs and rabbits, respectively. Animal protection was observed only when RNAase was injected into the site of viral administration. The Intramuscular injection of RNAase, other than the site of viral administration failed to protect the infected animals, the efficacy (75%) of RNAase Injected into the rabbits was similar 1 and 24 hours after animal infection.

Original languageEnglish
Pages (from-to)41-43
Number of pages3
JournalVoprosy Virusologii
Volume51
Issue number5
Publication statusPublished - 2006

Fingerprint

Rabies virus
Bacillus
Antiviral Agents
Guinea Pigs
Rabbits
Intramuscular Injections
Control Groups
Injections
Infection

Keywords

  • Animal protection
  • Bacillus intermedius RNAase
  • Guinea-pigs
  • Outdoor rabies virus
  • Rabbits

ASJC Scopus subject areas

  • Virology

Cite this

Gribencha, S. V., Potseluyeva, L. A., Barinsky, I. F., Deyev, S. M., Balandin, T. G., & Leshchinskaya, I. B. (2006). Antiviral activity of Bacillus intermedius RNAase in guinea-pigs and rabbits infected with outdoor rabies virus. Voprosy Virusologii, 51(5), 41-43.

Antiviral activity of Bacillus intermedius RNAase in guinea-pigs and rabbits infected with outdoor rabies virus. / Gribencha, S. V.; Potseluyeva, L. A.; Barinsky, I. F.; Deyev, S. M.; Balandin, T. G.; Leshchinskaya, I. B.

In: Voprosy Virusologii, Vol. 51, No. 5, 2006, p. 41-43.

Research output: Contribution to journalArticle

Gribencha, SV, Potseluyeva, LA, Barinsky, IF, Deyev, SM, Balandin, TG & Leshchinskaya, IB 2006, 'Antiviral activity of Bacillus intermedius RNAase in guinea-pigs and rabbits infected with outdoor rabies virus', Voprosy Virusologii, vol. 51, no. 5, pp. 41-43.
Gribencha SV, Potseluyeva LA, Barinsky IF, Deyev SM, Balandin TG, Leshchinskaya IB. Antiviral activity of Bacillus intermedius RNAase in guinea-pigs and rabbits infected with outdoor rabies virus. Voprosy Virusologii. 2006;51(5):41-43.
Gribencha, S. V. ; Potseluyeva, L. A. ; Barinsky, I. F. ; Deyev, S. M. ; Balandin, T. G. ; Leshchinskaya, I. B. / Antiviral activity of Bacillus intermedius RNAase in guinea-pigs and rabbits infected with outdoor rabies virus. In: Voprosy Virusologii. 2006 ; Vol. 51, No. 5. pp. 41-43.
@article{5d3e958ab0df4dd790c824dbaf795a97,
title = "Antiviral activity of Bacillus intermedius RNAase in guinea-pigs and rabbits infected with outdoor rabies virus",
abstract = "Single injection of Bacillus intermedius RNAase in a dose of 5 mg/kg could protect 40 and 50-70{\%} of the outdoor rabies virus-preinfected guinea-pigs and rabbits, respectively. In the control group there were 100 and 75-100{\%} deaths of the RNAase-untreated guinea-pigs and rabbits, respectively. Animal protection was observed only when RNAase was injected into the site of viral administration. The Intramuscular injection of RNAase, other than the site of viral administration failed to protect the infected animals, the efficacy (75{\%}) of RNAase Injected into the rabbits was similar 1 and 24 hours after animal infection.",
keywords = "Animal protection, Bacillus intermedius RNAase, Guinea-pigs, Outdoor rabies virus, Rabbits",
author = "Gribencha, {S. V.} and Potseluyeva, {L. A.} and Barinsky, {I. F.} and Deyev, {S. M.} and Balandin, {T. G.} and Leshchinskaya, {I. B.}",
year = "2006",
language = "English",
volume = "51",
pages = "41--43",
journal = "Voprosy Virusologii",
issn = "0507-4088",
publisher = "Izdatelstvo Meditsina",
number = "5",

}

TY - JOUR

T1 - Antiviral activity of Bacillus intermedius RNAase in guinea-pigs and rabbits infected with outdoor rabies virus

AU - Gribencha, S. V.

AU - Potseluyeva, L. A.

AU - Barinsky, I. F.

AU - Deyev, S. M.

AU - Balandin, T. G.

AU - Leshchinskaya, I. B.

PY - 2006

Y1 - 2006

N2 - Single injection of Bacillus intermedius RNAase in a dose of 5 mg/kg could protect 40 and 50-70% of the outdoor rabies virus-preinfected guinea-pigs and rabbits, respectively. In the control group there were 100 and 75-100% deaths of the RNAase-untreated guinea-pigs and rabbits, respectively. Animal protection was observed only when RNAase was injected into the site of viral administration. The Intramuscular injection of RNAase, other than the site of viral administration failed to protect the infected animals, the efficacy (75%) of RNAase Injected into the rabbits was similar 1 and 24 hours after animal infection.

AB - Single injection of Bacillus intermedius RNAase in a dose of 5 mg/kg could protect 40 and 50-70% of the outdoor rabies virus-preinfected guinea-pigs and rabbits, respectively. In the control group there were 100 and 75-100% deaths of the RNAase-untreated guinea-pigs and rabbits, respectively. Animal protection was observed only when RNAase was injected into the site of viral administration. The Intramuscular injection of RNAase, other than the site of viral administration failed to protect the infected animals, the efficacy (75%) of RNAase Injected into the rabbits was similar 1 and 24 hours after animal infection.

KW - Animal protection

KW - Bacillus intermedius RNAase

KW - Guinea-pigs

KW - Outdoor rabies virus

KW - Rabbits

UR - http://www.scopus.com/inward/record.url?scp=33750707531&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33750707531&partnerID=8YFLogxK

M3 - Article

VL - 51

SP - 41

EP - 43

JO - Voprosy Virusologii

JF - Voprosy Virusologii

SN - 0507-4088

IS - 5

ER -