Abstract
The antihypoxic activity of humic acids of Tomsk lowland peat was studied experimentally. It was established that native humic acids of peat (HAP) had pronounced antihypoxic activity after a preventive intragastric administration to mice, increasing the lifespan of animals and decreasing the lethality under hypobaric hypoxic and histotoxic hypoxia conditions. The discovered antihypoxic properties of HAP were probably due to their protective antioxidant properties, which prevent free-radical injury to cells and organelles under hypoxia conditions.
| Original language | English |
|---|---|
| Pages (from-to) | 97-99 |
| Number of pages | 3 |
| Journal | Pharmaceutical Chemistry Journal |
| Volume | 48 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2014 |
Keywords
- Antihypoxic activity
- Humic acids
- Peat
ASJC Scopus subject areas
- Drug Discovery
- Pharmacology
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Belousov, M. V., Akhmedzhanov, R. R., Zykova, M. V., Arbuzov, A. N., Gur'ev, A. M., & Yusubov, M. S. (2014). Antihypoxic activity of native humic acids of Tomsk lowland peat. Pharmaceutical Chemistry Journal, 48(2), 97-99. https://doi.org/10.1007/s11094-014-1056-0