Antihypoxic activity of native humic acids of Tomsk lowland peat

Abstract

The antihypoxic activity of humic acids of Tomsk lowland peat was studied experimentally. It was established that native humic acids of peat (HAP) had pronounced antihypoxic activity after a preventive intragastric administration to mice, increasing the lifespan of animals and decreasing the lethality under hypobaric hypoxic and histotoxic hypoxia conditions. The discovered antihypoxic properties of HAP were probably due to their protective antioxidant properties, which prevent free-radical injury to cells and organelles under hypoxia conditions.

Original language	English
Pages (from-to)	97-99
Number of pages	3
Journal	Pharmaceutical Chemistry Journal
Volume	48
Issue number	2
DOIs	https://doi.org/10.1007/s11094-014-1056-0
Publication status	Published - 2014

Keywords

Antihypoxic activity
Humic acids
Peat

ASJC Scopus subject areas

Drug Discovery
Pharmacology

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10.1007/s11094-014-1056-0

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title = "Antihypoxic activity of native humic acids of Tomsk lowland peat",

abstract = "The antihypoxic activity of humic acids of Tomsk lowland peat was studied experimentally. It was established that native humic acids of peat (HAP) had pronounced antihypoxic activity after a preventive intragastric administration to mice, increasing the lifespan of animals and decreasing the lethality under hypobaric hypoxic and histotoxic hypoxia conditions. The discovered antihypoxic properties of HAP were probably due to their protective antioxidant properties, which prevent free-radical injury to cells and organelles under hypoxia conditions.",

keywords = "Antihypoxic activity, Humic acids, Peat",

author = "Belousov, {M. V.} and Akhmedzhanov, {R. R.} and Zykova, {M. V.} and Arbuzov, {A. N.} and Gur'ev, {A. M.} and Yusubov, {M. S.}",

year = "2014",

doi = "10.1007/s11094-014-1056-0",

language = "English",

volume = "48",

pages = "97--99",

journal = "Pharmaceutical Chemistry Journal",

issn = "0091-150X",

publisher = "Springer New York",

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T1 - Antihypoxic activity of native humic acids of Tomsk lowland peat

AU - Belousov, M. V.

AU - Akhmedzhanov, R. R.

AU - Zykova, M. V.

AU - Arbuzov, A. N.

AU - Gur'ev, A. M.

AU - Yusubov, M. S.

PY - 2014

Y1 - 2014

N2 - The antihypoxic activity of humic acids of Tomsk lowland peat was studied experimentally. It was established that native humic acids of peat (HAP) had pronounced antihypoxic activity after a preventive intragastric administration to mice, increasing the lifespan of animals and decreasing the lethality under hypobaric hypoxic and histotoxic hypoxia conditions. The discovered antihypoxic properties of HAP were probably due to their protective antioxidant properties, which prevent free-radical injury to cells and organelles under hypoxia conditions.

AB - The antihypoxic activity of humic acids of Tomsk lowland peat was studied experimentally. It was established that native humic acids of peat (HAP) had pronounced antihypoxic activity after a preventive intragastric administration to mice, increasing the lifespan of animals and decreasing the lethality under hypobaric hypoxic and histotoxic hypoxia conditions. The discovered antihypoxic properties of HAP were probably due to their protective antioxidant properties, which prevent free-radical injury to cells and organelles under hypoxia conditions.

KW - Antihypoxic activity

KW - Humic acids

KW - Peat

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EP - 99

JO - Pharmaceutical Chemistry Journal

JF - Pharmaceutical Chemistry Journal

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