Anticancer drug delivery system based on calcium carbonate particles loaded with a photosensitizer

Yulia Svenskaya, Bogdan Parakhonskiy, Albrecht Haase, Vsevolod Atkin, Evgeny Lukyanets, Dmitry Gorin, Renzo Antolini

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

In photodynamic therapy (PDT), photosensitizers are required to arrive in high concentrations at selective targets like cancer cells avoiding toxicity in healthy tissue. In this work, we propose the application of porous calcium carbonate carriers in the form of polycrystalline vaterite for this task.We investigated the loading efficiency for the photosensitizer Photosens in vaterite micro- and nanocarriers. A possible release mechanism depending on the surrounding pH was studied, showing a fast degradation of the carriers in buffers below pH 7. These results hold out the prospect of a novel PDT drug delivery system. Variation of particle size or additional coatings allow custom-design of workload release curves. An intrinsic cancer-sensitivity can be expected from the pH-dependent release in the acidic microenvironment of cancer tissue.

Original languageEnglish
Pages (from-to)11-15
Number of pages5
JournalBiophysical Chemistry
Volume182
DOIs
Publication statusPublished - 2013
Externally publishedYes

Fingerprint

Photosensitizing Agents
Calcium Carbonate
Drug Delivery Systems
Photodynamic therapy
Photochemotherapy
Tissue
Tumor Microenvironment
Workload
Particle Size
Toxicity
Neoplasms
Buffers
Particle size
Cells
Degradation
Coatings

Keywords

  • Calcium carbonate
  • Cancer
  • Drug delivery
  • Photosens
  • Phthalocyanine
  • Vaterite

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Organic Chemistry

Cite this

Svenskaya, Y., Parakhonskiy, B., Haase, A., Atkin, V., Lukyanets, E., Gorin, D., & Antolini, R. (2013). Anticancer drug delivery system based on calcium carbonate particles loaded with a photosensitizer. Biophysical Chemistry, 182, 11-15. https://doi.org/10.1016/j.bpc.2013.07.006

Anticancer drug delivery system based on calcium carbonate particles loaded with a photosensitizer. / Svenskaya, Yulia; Parakhonskiy, Bogdan; Haase, Albrecht; Atkin, Vsevolod; Lukyanets, Evgeny; Gorin, Dmitry; Antolini, Renzo.

In: Biophysical Chemistry, Vol. 182, 2013, p. 11-15.

Research output: Contribution to journalArticle

Svenskaya, Y, Parakhonskiy, B, Haase, A, Atkin, V, Lukyanets, E, Gorin, D & Antolini, R 2013, 'Anticancer drug delivery system based on calcium carbonate particles loaded with a photosensitizer', Biophysical Chemistry, vol. 182, pp. 11-15. https://doi.org/10.1016/j.bpc.2013.07.006
Svenskaya, Yulia ; Parakhonskiy, Bogdan ; Haase, Albrecht ; Atkin, Vsevolod ; Lukyanets, Evgeny ; Gorin, Dmitry ; Antolini, Renzo. / Anticancer drug delivery system based on calcium carbonate particles loaded with a photosensitizer. In: Biophysical Chemistry. 2013 ; Vol. 182. pp. 11-15.
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