Anticancer drug delivery system based on calcium carbonate particles loaded with a photosensitizer

Yulia Svenskaya, Bogdan Parakhonskiy, Albrecht Haase, Vsevolod Atkin, Evgeny Lukyanets, Dmitry Gorin, Renzo Antolini

Research output: Contribution to journalArticlepeer-review

100 Citations (Scopus)

Abstract

In photodynamic therapy (PDT), photosensitizers are required to arrive in high concentrations at selective targets like cancer cells avoiding toxicity in healthy tissue. In this work, we propose the application of porous calcium carbonate carriers in the form of polycrystalline vaterite for this task.We investigated the loading efficiency for the photosensitizer Photosens in vaterite micro- and nanocarriers. A possible release mechanism depending on the surrounding pH was studied, showing a fast degradation of the carriers in buffers below pH 7. These results hold out the prospect of a novel PDT drug delivery system. Variation of particle size or additional coatings allow custom-design of workload release curves. An intrinsic cancer-sensitivity can be expected from the pH-dependent release in the acidic microenvironment of cancer tissue.

Original languageEnglish
Pages (from-to)11-15
Number of pages5
JournalBiophysical Chemistry
Volume182
DOIs
Publication statusPublished - 2013
Externally publishedYes

Keywords

  • Calcium carbonate
  • Cancer
  • Drug delivery
  • Photosens
  • Phthalocyanine
  • Vaterite

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Organic Chemistry

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