Abstract
In photodynamic therapy (PDT), photosensitizers are required to arrive in high concentrations at selective targets like cancer cells avoiding toxicity in healthy tissue. In this work, we propose the application of porous calcium carbonate carriers in the form of polycrystalline vaterite for this task.We investigated the loading efficiency for the photosensitizer Photosens in vaterite micro- and nanocarriers. A possible release mechanism depending on the surrounding pH was studied, showing a fast degradation of the carriers in buffers below pH 7. These results hold out the prospect of a novel PDT drug delivery system. Variation of particle size or additional coatings allow custom-design of workload release curves. An intrinsic cancer-sensitivity can be expected from the pH-dependent release in the acidic microenvironment of cancer tissue.
| Original language | English |
|---|---|
| Pages (from-to) | 11-15 |
| Number of pages | 5 |
| Journal | Biophysical Chemistry |
| Volume | 182 |
| DOIs | |
| Publication status | Published - 2013 |
| Externally published | Yes |
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Keywords
- Calcium carbonate
- Cancer
- Drug delivery
- Photosens
- Phthalocyanine
- Vaterite
ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Organic Chemistry
Cite this
Anticancer drug delivery system based on calcium carbonate particles loaded with a photosensitizer. / Svenskaya, Yulia; Parakhonskiy, Bogdan; Haase, Albrecht; Atkin, Vsevolod; Lukyanets, Evgeny; Gorin, Dmitry; Antolini, Renzo.
In: Biophysical Chemistry, Vol. 182, 2013, p. 11-15.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Anticancer drug delivery system based on calcium carbonate particles loaded with a photosensitizer
AU - Svenskaya, Yulia
AU - Parakhonskiy, Bogdan
AU - Haase, Albrecht
AU - Atkin, Vsevolod
AU - Lukyanets, Evgeny
AU - Gorin, Dmitry
AU - Antolini, Renzo
PY - 2013
Y1 - 2013
N2 - In photodynamic therapy (PDT), photosensitizers are required to arrive in high concentrations at selective targets like cancer cells avoiding toxicity in healthy tissue. In this work, we propose the application of porous calcium carbonate carriers in the form of polycrystalline vaterite for this task.We investigated the loading efficiency for the photosensitizer Photosens in vaterite micro- and nanocarriers. A possible release mechanism depending on the surrounding pH was studied, showing a fast degradation of the carriers in buffers below pH 7. These results hold out the prospect of a novel PDT drug delivery system. Variation of particle size or additional coatings allow custom-design of workload release curves. An intrinsic cancer-sensitivity can be expected from the pH-dependent release in the acidic microenvironment of cancer tissue.
AB - In photodynamic therapy (PDT), photosensitizers are required to arrive in high concentrations at selective targets like cancer cells avoiding toxicity in healthy tissue. In this work, we propose the application of porous calcium carbonate carriers in the form of polycrystalline vaterite for this task.We investigated the loading efficiency for the photosensitizer Photosens in vaterite micro- and nanocarriers. A possible release mechanism depending on the surrounding pH was studied, showing a fast degradation of the carriers in buffers below pH 7. These results hold out the prospect of a novel PDT drug delivery system. Variation of particle size or additional coatings allow custom-design of workload release curves. An intrinsic cancer-sensitivity can be expected from the pH-dependent release in the acidic microenvironment of cancer tissue.
KW - Calcium carbonate
KW - Cancer
KW - Drug delivery
KW - Photosens
KW - Phthalocyanine
KW - Vaterite
UR - http://www.scopus.com/inward/record.url?scp=84885184475&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84885184475&partnerID=8YFLogxK
U2 - 10.1016/j.bpc.2013.07.006
DO - 10.1016/j.bpc.2013.07.006
M3 - Article
C2 - 23932207
AN - SCOPUS:84885184475
VL - 182
SP - 11
EP - 15
JO - Biophysical Chemistry
JF - Biophysical Chemistry
SN - 0301-4622
ER -