Antibody engineering: Molecular constructor on the basis of barnase-barstar module

S. M. Deev, E. N. Lebedenko

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Today, antibody engineering for clinical applications is a rapidly progressing field of science and a big business. The basic functions of an antibody can be spatially differentiated and attributed to various structural domains of a molecule. Therefore, each of them may be an object for engineering with the aim of using a definite antibody function. In this sense, the potential of antibodies is unique. In this article, recent achievements and current problems of antibody engineering are briefly reviewed. The main attention is focused on a molecular constructor that allows for obtaining, with the help of a versatile barnase-barstar module, mono- and multivalent miniantibodies and their derivatives with outlined properties.

Original languageEnglish
Pages (from-to)685-701
Number of pages17
JournalRussian Journal of Bioorganic Chemistry
Volume35
Issue number6
DOIs
Publication statusPublished - Nov 2009
Externally publishedYes

Keywords

  • Barnase-barstar module
  • Bispecificity
  • Multivalency
  • Single chain antibodies
  • Targeted delivery

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry

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