Antibody engineering: Molecular constructor on the basis of barnase-barstar module

Abstract

Today, antibody engineering for clinical applications is a rapidly progressing field of science and a big business. The basic functions of an antibody can be spatially differentiated and attributed to various structural domains of a molecule. Therefore, each of them may be an object for engineering with the aim of using a definite antibody function. In this sense, the potential of antibodies is unique. In this article, recent achievements and current problems of antibody engineering are briefly reviewed. The main attention is focused on a molecular constructor that allows for obtaining, with the help of a versatile barnase-barstar module, mono- and multivalent miniantibodies and their derivatives with outlined properties.

Original language	English
Pages (from-to)	685-701
Number of pages	17
Journal	Russian Journal of Bioorganic Chemistry
Volume	35
Issue number	6
DOIs	https://doi.org/10.1134/S1068162009060041
Publication status	Published - Nov 2009
Externally published	Yes

Keywords

Barnase-barstar module
Bispecificity
Multivalency
Single chain antibodies
Targeted delivery

ASJC Scopus subject areas

Biochemistry
Organic Chemistry

Access to Document

10.1134/S1068162009060041

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title = "Antibody engineering: Molecular constructor on the basis of barnase-barstar module",

abstract = "Today, antibody engineering for clinical applications is a rapidly progressing field of science and a big business. The basic functions of an antibody can be spatially differentiated and attributed to various structural domains of a molecule. Therefore, each of them may be an object for engineering with the aim of using a definite antibody function. In this sense, the potential of antibodies is unique. In this article, recent achievements and current problems of antibody engineering are briefly reviewed. The main attention is focused on a molecular constructor that allows for obtaining, with the help of a versatile barnase-barstar module, mono- and multivalent miniantibodies and their derivatives with outlined properties.",

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