Antibody engineering: barnase-barstar module as a molecular constructor

S. M. Deev, E. N. Labedenko

Research output: Contribution to journalReview articlepeer-review

5 Citations (Scopus)

Abstract

Today, antibody engineering for clinical applications is a rapidly progressing field of science and a big business. The basic functions of an antibody can be spatially differentiated and attributed to various structural domains of a molecule. Therefore, each of them may be an object for engineering with the aim of using a definite antibody function. In this sense, the potential of antibodies is unique. In this article, recent achievements and current problems of antibody engineering are briefly reviewed. The main attention is focused on a molecular constructor that allows for obtaining, with the help of a versatile barnase-barstar module, mono- and multiva-lent miniantibodies and their derivatives with outlined properties.

Original languageEnglish
Pages (from-to)761-778
Number of pages18
JournalBioorganicheskaia khimiia
Volume35
Issue number6
Publication statusPublished - Nov 2009

ASJC Scopus subject areas

  • Medicine(all)

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