Antibacterial AgNPs/CaP biocomposites

Abstract

The modification of implant surface is in the focus of many scientists worldwide. In this study, multifunctional biocomposite on the basis of calcium phosphate coating and silver nanoparticles has been fabricated through the use of nanofabrication techniques. Dense nanocrystalline HA film was deposited over AgNPs. The properties as well as the in vitro behavior of the developed biocomposites have been studied. The diffraction patterns of the biocomposites revealed the peaks of crystalline HA and silver (Ag). The release of Ag from the developed biocomposites was evaluated. The concentration of the released silver ions for 7 days of dissolution was 0.27±0.02 μg/mL and 0.54±0.02 μg/mL for phosphate and acetate buffers, respectively. In order to estimate the cytotoxicity of the samples the functional activity of osteoclasts, in particular, cell morphology, multinuclearity, actin ring and resorption pit on the substrates coated with HA and AgNPs-HA have been evaluated.

Original language	English
Title of host publication	2014 9th International Forum on Strategic Technology, IFOST 2014
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	472-474
Number of pages	3
ISBN (Print)	9781479960620
DOIs	https://doi.org/10.1109/IFOST.2014.6991166
Publication status	Published - 17 Dec 2014
Event	9th International Forum on Strategic Technology, IFOST 2014 - Cox's Bazar, Bangladesh Duration: 21 Oct 2014 → 23 Oct 2014

Other

Other	9th International Forum on Strategic Technology, IFOST 2014
Country	Bangladesh
City	Cox's Bazar
Period	21.10.14 → 23.10.14

Keywords

hydroxyapatite
multilayer structures
RF magnetron sputtering
silver nanoparticles
thin films

ASJC Scopus subject areas

Energy Engineering and Power Technology
Civil and Structural Engineering
Building and Construction
Fuel Technology
Computer Networks and Communications

Access to Document

10.1109/IFOST.2014.6991166

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Ivanova, A. A., Surmenev, R. A., Surmeneva, M. A., Mukhametkaliyev, TM., Sharonova, A. A., Grubova, I. Y., Loza, K., Chernousova, S., Prymak, O., & Epple, M. (2014). Antibacterial AgNPs/CaP biocomposites. In 2014 9th International Forum on Strategic Technology, IFOST 2014 (pp. 472-474). [6991166] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/IFOST.2014.6991166

Antibacterial AgNPs/CaP biocomposites. / Ivanova, A. A.; Surmenev, R. A.; Surmeneva, M. A.; Mukhametkaliyev, Timur Mukhamedrashidovich; Sharonova, A. A.; Grubova, I. Yu; Loza, K.; Chernousova, S.; Prymak, O.; Epple, M.

2014 9th International Forum on Strategic Technology, IFOST 2014. Institute of Electrical and Electronics Engineers Inc., 2014. p. 472-474 6991166.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Ivanova, AA , Surmenev, RA , Surmeneva, MA, Mukhametkaliyev, TM, Sharonova, AA , Grubova, IY, Loza, K, Chernousova, S, Prymak, O & Epple, M 2014, Antibacterial AgNPs/CaP biocomposites. in 2014 9th International Forum on Strategic Technology, IFOST 2014., 6991166, Institute of Electrical and Electronics Engineers Inc., pp. 472-474, 9th International Forum on Strategic Technology, IFOST 2014, Cox's Bazar, Bangladesh, 21.10.14. https://doi.org/10.1109/IFOST.2014.6991166

Ivanova, A. A. ; Surmenev, R. A. ; Surmeneva, M. A. ; Mukhametkaliyev, Timur Mukhamedrashidovich ; Sharonova, A. A. ; Grubova, I. Yu ; Loza, K. ; Chernousova, S. ; Prymak, O. ; Epple, M. / Antibacterial AgNPs/CaP biocomposites. 2014 9th International Forum on Strategic Technology, IFOST 2014. Institute of Electrical and Electronics Engineers Inc., 2014. pp. 472-474

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title = "Antibacterial AgNPs/CaP biocomposites",

abstract = "The modification of implant surface is in the focus of many scientists worldwide. In this study, multifunctional biocomposite on the basis of calcium phosphate coating and silver nanoparticles has been fabricated through the use of nanofabrication techniques. Dense nanocrystalline HA film was deposited over AgNPs. The properties as well as the in vitro behavior of the developed biocomposites have been studied. The diffraction patterns of the biocomposites revealed the peaks of crystalline HA and silver (Ag). The release of Ag from the developed biocomposites was evaluated. The concentration of the released silver ions for 7 days of dissolution was 0.27±0.02 μg/mL and 0.54±0.02 μg/mL for phosphate and acetate buffers, respectively. In order to estimate the cytotoxicity of the samples the functional activity of osteoclasts, in particular, cell morphology, multinuclearity, actin ring and resorption pit on the substrates coated with HA and AgNPs-HA have been evaluated.",

keywords = "hydroxyapatite, multilayer structures, RF magnetron sputtering, silver nanoparticles, thin films",

author = "Ivanova, {A. A.} and Surmenev, {R. A.} and Surmeneva, {M. A.} and Timur Mukhamedrashidovich Mukhametkaliyev and Sharonova, {A. A.} and Grubova, {I. Yu} and K. Loza and S. Chernousova and O. Prymak and M. Epple",

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AU - Sharonova, A. A.

AU - Grubova, I. Yu

AU - Loza, K.

AU - Chernousova, S.

AU - Prymak, O.

AU - Epple, M.

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N2 - The modification of implant surface is in the focus of many scientists worldwide. In this study, multifunctional biocomposite on the basis of calcium phosphate coating and silver nanoparticles has been fabricated through the use of nanofabrication techniques. Dense nanocrystalline HA film was deposited over AgNPs. The properties as well as the in vitro behavior of the developed biocomposites have been studied. The diffraction patterns of the biocomposites revealed the peaks of crystalline HA and silver (Ag). The release of Ag from the developed biocomposites was evaluated. The concentration of the released silver ions for 7 days of dissolution was 0.27±0.02 μg/mL and 0.54±0.02 μg/mL for phosphate and acetate buffers, respectively. In order to estimate the cytotoxicity of the samples the functional activity of osteoclasts, in particular, cell morphology, multinuclearity, actin ring and resorption pit on the substrates coated with HA and AgNPs-HA have been evaluated.

AB - The modification of implant surface is in the focus of many scientists worldwide. In this study, multifunctional biocomposite on the basis of calcium phosphate coating and silver nanoparticles has been fabricated through the use of nanofabrication techniques. Dense nanocrystalline HA film was deposited over AgNPs. The properties as well as the in vitro behavior of the developed biocomposites have been studied. The diffraction patterns of the biocomposites revealed the peaks of crystalline HA and silver (Ag). The release of Ag from the developed biocomposites was evaluated. The concentration of the released silver ions for 7 days of dissolution was 0.27±0.02 μg/mL and 0.54±0.02 μg/mL for phosphate and acetate buffers, respectively. In order to estimate the cytotoxicity of the samples the functional activity of osteoclasts, in particular, cell morphology, multinuclearity, actin ring and resorption pit on the substrates coated with HA and AgNPs-HA have been evaluated.

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KW - multilayer structures

KW - RF magnetron sputtering

KW - silver nanoparticles

KW - thin films

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