Abstract
The modification of implant surface is in the focus of many scientists worldwide. In this study, multifunctional biocomposite on the basis of calcium phosphate coating and silver nanoparticles has been fabricated through the use of nanofabrication techniques. Dense nanocrystalline HA film was deposited over AgNPs. The properties as well as the in vitro behavior of the developed biocomposites have been studied. The diffraction patterns of the biocomposites revealed the peaks of crystalline HA and silver (Ag). The release of Ag from the developed biocomposites was evaluated. The concentration of the released silver ions for 7 days of dissolution was 0.27±0.02 μg/mL and 0.54±0.02 μg/mL for phosphate and acetate buffers, respectively. In order to estimate the cytotoxicity of the samples the functional activity of osteoclasts, in particular, cell morphology, multinuclearity, actin ring and resorption pit on the substrates coated with HA and AgNPs-HA have been evaluated.
| Original language | English |
|---|---|
| Title of host publication | 2014 9th International Forum on Strategic Technology, IFOST 2014 |
| Publisher | Institute of Electrical and Electronics Engineers Inc. |
| Pages | 472-474 |
| Number of pages | 3 |
| ISBN (Print) | 9781479960620 |
| DOIs | |
| Publication status | Published - 17 Dec 2014 |
| Event | 9th International Forum on Strategic Technology, IFOST 2014 - Cox's Bazar, Bangladesh Duration: 21 Oct 2014 → 23 Oct 2014 |
Other
| Other | 9th International Forum on Strategic Technology, IFOST 2014 |
|---|---|
| Country | Bangladesh |
| City | Cox's Bazar |
| Period | 21.10.14 → 23.10.14 |
Fingerprint
Keywords
- hydroxyapatite
- multilayer structures
- RF magnetron sputtering
- silver nanoparticles
- thin films
ASJC Scopus subject areas
- Energy Engineering and Power Technology
- Civil and Structural Engineering
- Building and Construction
- Fuel Technology
- Computer Networks and Communications
Cite this
Antibacterial AgNPs/CaP biocomposites. / Ivanova, A. A.; Surmenev, R. A.; Surmeneva, M. A.; Mukhametkaliyev, Timur Mukhamedrashidovich; Sharonova, A. A.; Grubova, I. Yu; Loza, K.; Chernousova, S.; Prymak, O.; Epple, M.
2014 9th International Forum on Strategic Technology, IFOST 2014. Institute of Electrical and Electronics Engineers Inc., 2014. p. 472-474 6991166.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Antibacterial AgNPs/CaP biocomposites
AU - Ivanova, A. A.
AU - Surmenev, R. A.
AU - Surmeneva, M. A.
AU - Mukhametkaliyev, Timur Mukhamedrashidovich
AU - Sharonova, A. A.
AU - Grubova, I. Yu
AU - Loza, K.
AU - Chernousova, S.
AU - Prymak, O.
AU - Epple, M.
PY - 2014/12/17
Y1 - 2014/12/17
N2 - The modification of implant surface is in the focus of many scientists worldwide. In this study, multifunctional biocomposite on the basis of calcium phosphate coating and silver nanoparticles has been fabricated through the use of nanofabrication techniques. Dense nanocrystalline HA film was deposited over AgNPs. The properties as well as the in vitro behavior of the developed biocomposites have been studied. The diffraction patterns of the biocomposites revealed the peaks of crystalline HA and silver (Ag). The release of Ag from the developed biocomposites was evaluated. The concentration of the released silver ions for 7 days of dissolution was 0.27±0.02 μg/mL and 0.54±0.02 μg/mL for phosphate and acetate buffers, respectively. In order to estimate the cytotoxicity of the samples the functional activity of osteoclasts, in particular, cell morphology, multinuclearity, actin ring and resorption pit on the substrates coated with HA and AgNPs-HA have been evaluated.
AB - The modification of implant surface is in the focus of many scientists worldwide. In this study, multifunctional biocomposite on the basis of calcium phosphate coating and silver nanoparticles has been fabricated through the use of nanofabrication techniques. Dense nanocrystalline HA film was deposited over AgNPs. The properties as well as the in vitro behavior of the developed biocomposites have been studied. The diffraction patterns of the biocomposites revealed the peaks of crystalline HA and silver (Ag). The release of Ag from the developed biocomposites was evaluated. The concentration of the released silver ions for 7 days of dissolution was 0.27±0.02 μg/mL and 0.54±0.02 μg/mL for phosphate and acetate buffers, respectively. In order to estimate the cytotoxicity of the samples the functional activity of osteoclasts, in particular, cell morphology, multinuclearity, actin ring and resorption pit on the substrates coated with HA and AgNPs-HA have been evaluated.
KW - hydroxyapatite
KW - multilayer structures
KW - RF magnetron sputtering
KW - silver nanoparticles
KW - thin films
UR - http://www.scopus.com/inward/record.url?scp=84921273429&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84921273429&partnerID=8YFLogxK
U2 - 10.1109/IFOST.2014.6991166
DO - 10.1109/IFOST.2014.6991166
M3 - Conference contribution
SN - 9781479960620
SP - 472
EP - 474
BT - 2014 9th International Forum on Strategic Technology, IFOST 2014
PB - Institute of Electrical and Electronics Engineers Inc.
ER -