Abstract
It was shown that the agonist of peripherasl ORL1 receptors nociceptine raises heart resistance to the antiarrhythmic effect of aconitine. The antiarrhythmic effect of nociceptine is not conected with a change in the tonus of the autonomous nervous system or with an effect on opiate receptors. It is assumed that the antiarrhythmic properties of nociceptine are realized through inhibition of Na+/Ca2+ metabolism or blockade of rapid Na+-channels of the cardiomyocytes.
| Original language | English |
|---|---|
| Pages (from-to) | 24 |
| Number of pages | 1 |
| Journal | Eksperimental'naya i Klinicheskaya Farmakologiya |
| Volume | 62 |
| Issue number | 5 |
| Publication status | Published - 1999 |
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ASJC Scopus subject areas
- Pharmacology, Toxicology and Pharmaceutics(all)
Cite this
Antiarrhythmic properties of the functional opioid antagonist orphanine FQ (nociceptine). / Maslov, L. N.; Krylatov, A. V.; Lishmanov, Yu B.; Albrecht, E.
In: Eksperimental'naya i Klinicheskaya Farmakologiya, Vol. 62, No. 5, 1999, p. 24.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Antiarrhythmic properties of the functional opioid antagonist orphanine FQ (nociceptine)
AU - Maslov, L. N.
AU - Krylatov, A. V.
AU - Lishmanov, Yu B.
AU - Albrecht, E.
PY - 1999
Y1 - 1999
N2 - It was shown that the agonist of peripherasl ORL1 receptors nociceptine raises heart resistance to the antiarrhythmic effect of aconitine. The antiarrhythmic effect of nociceptine is not conected with a change in the tonus of the autonomous nervous system or with an effect on opiate receptors. It is assumed that the antiarrhythmic properties of nociceptine are realized through inhibition of Na+/Ca2+ metabolism or blockade of rapid Na+-channels of the cardiomyocytes.
AB - It was shown that the agonist of peripherasl ORL1 receptors nociceptine raises heart resistance to the antiarrhythmic effect of aconitine. The antiarrhythmic effect of nociceptine is not conected with a change in the tonus of the autonomous nervous system or with an effect on opiate receptors. It is assumed that the antiarrhythmic properties of nociceptine are realized through inhibition of Na+/Ca2+ metabolism or blockade of rapid Na+-channels of the cardiomyocytes.
UR - http://www.scopus.com/inward/record.url?scp=0042261777&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0042261777&partnerID=8YFLogxK
M3 - Article
VL - 62
SP - 24
JO - Eksperimental'naya i Klinicheskaya Farmakologiya
JF - Eksperimental'naya i Klinicheskaya Farmakologiya
SN - 0869-2092
IS - 5
ER -