It was shown that the agonist of peripherasl ORL1 receptors nociceptine raises heart resistance to the antiarrhythmic effect of aconitine. The antiarrhythmic effect of nociceptine is not conected with a change in the tonus of the autonomous nervous system or with an effect on opiate receptors. It is assumed that the antiarrhythmic properties of nociceptine are realized through inhibition of Na+/Ca2+ metabolism or blockade of rapid Na+-channels of the cardiomyocytes.
|Number of pages||1|
|Journal||Eksperimental'naya i Klinicheskaya Farmakologiya|
|Publication status||Published - 1999|
ASJC Scopus subject areas
- Pharmacology, Toxicology and Pharmaceutics(all)