Antiarrhythmic properties of the functional opioid antagonist orphanine FQ (nociceptine)

L. N. Maslov, A. V. Krylatov, Yu B. Lishmanov, E. Albrecht

Research output: Contribution to journalArticlepeer-review


It was shown that the agonist of peripherasl ORL1 receptors nociceptine raises heart resistance to the antiarrhythmic effect of aconitine. The antiarrhythmic effect of nociceptine is not conected with a change in the tonus of the autonomous nervous system or with an effect on opiate receptors. It is assumed that the antiarrhythmic properties of nociceptine are realized through inhibition of Na+/Ca2+ metabolism or blockade of rapid Na+-channels of the cardiomyocytes.

Original languageEnglish
Pages (from-to)24
Number of pages1
JournalEksperimental'naya i Klinicheskaya Farmakologiya
Issue number5
Publication statusPublished - 1999

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)

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