Antiarrhythmic properties of the functional opioid antagonist orphanine FQ (nociceptine)

Abstract

It was shown that the agonist of peripherasl ORL₁ receptors nociceptine raises heart resistance to the antiarrhythmic effect of aconitine. The antiarrhythmic effect of nociceptine is not conected with a change in the tonus of the autonomous nervous system or with an effect on opiate receptors. It is assumed that the antiarrhythmic properties of nociceptine are realized through inhibition of Na⁺/Ca²⁺ metabolism or blockade of rapid Na⁺-channels of the cardiomyocytes.

Original language	English
Pages (from-to)	24
Number of pages	1
Journal	Eksperimental'naya i Klinicheskaya Farmakologiya
Volume	62
Issue number	5
Publication status	Published - 1999

ASJC Scopus subject areas

Pharmacology, Toxicology and Pharmaceutics(all)

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title = "Antiarrhythmic properties of the functional opioid antagonist orphanine FQ (nociceptine)",

abstract = "It was shown that the agonist of peripherasl ORL1 receptors nociceptine raises heart resistance to the antiarrhythmic effect of aconitine. The antiarrhythmic effect of nociceptine is not conected with a change in the tonus of the autonomous nervous system or with an effect on opiate receptors. It is assumed that the antiarrhythmic properties of nociceptine are realized through inhibition of Na+/Ca2+ metabolism or blockade of rapid Na+-channels of the cardiomyocytes.",

author = "Maslov, {L. N.} and Krylatov, {A. V.} and Lishmanov, {Yu B.} and E. Albrecht",

year = "1999",

language = "English",

volume = "62",

pages = "24",

journal = "Eksperimental'naya i Klinicheskaya Farmakologiya",

issn = "0869-2092",

publisher = "Izdatelstvo Meditsina",

number = "5",

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T1 - Antiarrhythmic properties of the functional opioid antagonist orphanine FQ (nociceptine)

AU - Maslov, L. N.

AU - Krylatov, A. V.

AU - Lishmanov, Yu B.

AU - Albrecht, E.

PY - 1999

Y1 - 1999

N2 - It was shown that the agonist of peripherasl ORL1 receptors nociceptine raises heart resistance to the antiarrhythmic effect of aconitine. The antiarrhythmic effect of nociceptine is not conected with a change in the tonus of the autonomous nervous system or with an effect on opiate receptors. It is assumed that the antiarrhythmic properties of nociceptine are realized through inhibition of Na+/Ca2+ metabolism or blockade of rapid Na+-channels of the cardiomyocytes.

AB - It was shown that the agonist of peripherasl ORL1 receptors nociceptine raises heart resistance to the antiarrhythmic effect of aconitine. The antiarrhythmic effect of nociceptine is not conected with a change in the tonus of the autonomous nervous system or with an effect on opiate receptors. It is assumed that the antiarrhythmic properties of nociceptine are realized through inhibition of Na+/Ca2+ metabolism or blockade of rapid Na+-channels of the cardiomyocytes.

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JO - Eksperimental'naya i Klinicheskaya Farmakologiya

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