Antiarrhythmic properties of the cannabinoid receptor agonist HU-210

L. N. Maslov, Yu B. Lishmanov, L. A. Maimeskulova, P. Mechoulam

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The cannabinoid (CB1) receptor agonist HU-210 (0.5 mg/kg, i.v.) exhibited a pronounced antiarrhythmic effect in rats with the adrenaline (epinephrine) and aconitine induced arrhythmia models. At the same time, the intracerebrovascular introduction of HU-210 (500 or 5000 ng) did not affect the adrenaline-induced arrhythmia. The CB1 receptor pretreatment (blocking) with the SR 141716 antagonist (3 mg/kg) and the introduction of a ganglion blocker (hexamethonium, 10 mg/kg) did not inhibit the antiarrhythmic effect of HU-210. It is concluded that the antiarrhythmic effect of intravenously injected HU-210 is neither related to the CB 1 receptor activation nor mediated by the autonomous (vegetative) nervous system.

Original languageEnglish
Number of pages1
JournalEksperimental'naya i Klinicheskaya Farmakologiya
Issue number3
Publication statusPublished - 1 Jan 2001

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

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