Abstract
The μ-opiate receptor agonists DAGO and DALDA preinjected intravenously in a dose of 0.1 mg/kg prevented the occurrence of arrhythmias in rats injected with epinephrine. Their antiarrhythmic activity was not modified by atropine or hexamethonium. It is concluded that the vegetative nervous system plays no substantial role in mediating the antiarrhythmic effects of DAGO and DALDA, and that these effects are most likely associated with stimulation of cardiac opiate receptors.
| Original language | English |
|---|---|
| Pages (from-to) | 671-673 |
| Number of pages | 3 |
| Journal | Bulletin of Experimental Biology and Medicine |
| Volume | 122 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jul 1996 |
Keywords
- μ-receptor ligands
- arrhythmia
- vagus
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
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Maslov, L. N., Krylatov, A. V., & Lishmanov, Y. B. (1996). Antiarrhythmic effects of μ-opiate receptor agonists in rats with epinephrine-induced arrhythmias: Role of the vegetative nervous system. Bulletin of Experimental Biology and Medicine, 122(1), 671-673. https://doi.org/10.1007/BF02446018