Antiarrhythmic effects of μ-opiate receptor agonists in rats with epinephrine-induced arrhythmias

Role of the vegetative nervous system

L. N. Maslov, A. V. Krylatov, Yu B. Lishmanov

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The μ-opiate receptor agonists DAGO and DALDA preinjected intravenously in a dose of 0.1 mg/kg prevented the occurrence of arrhythmias in rats injected with epinephrine. Their antiarrhythmic activity was not modified by atropine or hexamethonium. It is concluded that the vegetative nervous system plays no substantial role in mediating the antiarrhythmic effects of DAGO and DALDA, and that these effects are most likely associated with stimulation of cardiac opiate receptors.

Original languageEnglish
Pages (from-to)671-673
Number of pages3
JournalBulletin of Experimental Biology and Medicine
Volume122
Issue number1
DOIs
Publication statusPublished - Jul 1996

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Ala(2)-MePhe(4)-Gly(5)-enkephalin
Autonomic Nervous System
Neurology
Opioid Receptors
Epinephrine
Rats
Cardiac Arrhythmias
Hexamethonium
Atropine
tyrosyl-arginyl-phenylalanyl-lysinamide

Keywords

  • μ-receptor ligands
  • arrhythmia
  • vagus

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

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