Antiarrhythmic effects of μ-opiate receptor agonists in rats with epinephrine-induced arrhythmias: Role of the vegetative nervous system

Abstract

The μ-opiate receptor agonists DAGO and DALDA preinjected intravenously in a dose of 0.1 mg/kg prevented the occurrence of arrhythmias in rats injected with epinephrine. Their antiarrhythmic activity was not modified by atropine or hexamethonium. It is concluded that the vegetative nervous system plays no substantial role in mediating the antiarrhythmic effects of DAGO and DALDA, and that these effects are most likely associated with stimulation of cardiac opiate receptors.

Original language	English
Pages (from-to)	671-673
Number of pages	3
Journal	Bulletin of Experimental Biology and Medicine
Volume	122
Issue number	1
DOIs	https://doi.org/10.1007/BF02446018
Publication status	Published - Jul 1996

Keywords

μ-receptor ligands
arrhythmia
vagus

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

Access to Document

10.1007/BF02446018

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title = "Antiarrhythmic effects of μ-opiate receptor agonists in rats with epinephrine-induced arrhythmias: Role of the vegetative nervous system",

abstract = "The μ-opiate receptor agonists DAGO and DALDA preinjected intravenously in a dose of 0.1 mg/kg prevented the occurrence of arrhythmias in rats injected with epinephrine. Their antiarrhythmic activity was not modified by atropine or hexamethonium. It is concluded that the vegetative nervous system plays no substantial role in mediating the antiarrhythmic effects of DAGO and DALDA, and that these effects are most likely associated with stimulation of cardiac opiate receptors.",

keywords = "μ-receptor ligands, arrhythmia, vagus",

author = "Maslov, {L. N.} and Krylatov, {A. V.} and Lishmanov, {Yu B.}",

year = "1996",

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T2 - Role of the vegetative nervous system

AU - Maslov, L. N.

AU - Krylatov, A. V.

AU - Lishmanov, Yu B.

PY - 1996/7

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AB - The μ-opiate receptor agonists DAGO and DALDA preinjected intravenously in a dose of 0.1 mg/kg prevented the occurrence of arrhythmias in rats injected with epinephrine. Their antiarrhythmic activity was not modified by atropine or hexamethonium. It is concluded that the vegetative nervous system plays no substantial role in mediating the antiarrhythmic effects of DAGO and DALDA, and that these effects are most likely associated with stimulation of cardiac opiate receptors.

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KW - vagus

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