Abstract
The μ-opiate receptor agonists DAGO and DALDA preinjected intravenously in a dose of 0.1 mg/kg prevented the occurrence of arrhythmias in rats injected with epinephrine. Their antiarrhythmic activity was not modified by atropine or hexamethonium. It is concluded that the vegetative nervous system plays no substantial role in mediating the antiarrhythmic effects of DAGO and DALDA, and that these effects are most likely associated with stimulation of cardiac opiate receptors.
| Original language | English |
|---|---|
| Pages (from-to) | 671-673 |
| Number of pages | 3 |
| Journal | Bulletin of Experimental Biology and Medicine |
| Volume | 122 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jul 1996 |
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Keywords
- μ-receptor ligands
- arrhythmia
- vagus
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Antiarrhythmic effects of μ-opiate receptor agonists in rats with epinephrine-induced arrhythmias : Role of the vegetative nervous system. / Maslov, L. N.; Krylatov, A. V.; Lishmanov, Yu B.
In: Bulletin of Experimental Biology and Medicine, Vol. 122, No. 1, 07.1996, p. 671-673.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Antiarrhythmic effects of μ-opiate receptor agonists in rats with epinephrine-induced arrhythmias
T2 - Role of the vegetative nervous system
AU - Maslov, L. N.
AU - Krylatov, A. V.
AU - Lishmanov, Yu B.
PY - 1996/7
Y1 - 1996/7
N2 - The μ-opiate receptor agonists DAGO and DALDA preinjected intravenously in a dose of 0.1 mg/kg prevented the occurrence of arrhythmias in rats injected with epinephrine. Their antiarrhythmic activity was not modified by atropine or hexamethonium. It is concluded that the vegetative nervous system plays no substantial role in mediating the antiarrhythmic effects of DAGO and DALDA, and that these effects are most likely associated with stimulation of cardiac opiate receptors.
AB - The μ-opiate receptor agonists DAGO and DALDA preinjected intravenously in a dose of 0.1 mg/kg prevented the occurrence of arrhythmias in rats injected with epinephrine. Their antiarrhythmic activity was not modified by atropine or hexamethonium. It is concluded that the vegetative nervous system plays no substantial role in mediating the antiarrhythmic effects of DAGO and DALDA, and that these effects are most likely associated with stimulation of cardiac opiate receptors.
KW - μ-receptor ligands
KW - arrhythmia
KW - vagus
UR - http://www.scopus.com/inward/record.url?scp=26944435593&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=26944435593&partnerID=8YFLogxK
U2 - 10.1007/BF02446018
DO - 10.1007/BF02446018
M3 - Article
VL - 122
SP - 671
EP - 673
JO - Bulletin of Experimental Biology and Medicine
JF - Bulletin of Experimental Biology and Medicine
SN - 0007-4888
IS - 1
ER -