Antiarrhythmic effect of hypoxic preconditioning is mediated by activation of μ- and δ-opioid receptors

E. V. Uskina, L. N. Maslov, Y. B. Lishmanov

Research output: Contribution to journalArticle

Abstract

Adaptation of rats to repetitive hypoxia leads to a decrease in the severity and frequency of arrhythmias induced by epinephrine. Naloxone abolishes antiarrhythmic effect of adaptation. Activation of μ-and δ-opioid receptors is one of the important factors mediating antiarrhythinic effect of adaptation. Intravenous administration of acetorphan, an enkefalinase inhibitor, produces statistically significant antiarrhythmic effect in the control group. Thus, the antiarrhythmic effect of hypoxic adaptation results from activation of μ- and δ-opioid receptors due to increased level of endogenous enkefalins.

Original languageEnglish
Pages (from-to)239-241
Number of pages3
JournalBulletin of Experimental Biology and Medicine
Volume125
Issue number3
DOIs
Publication statusPublished - 1 Jan 1998

Keywords

  • Arrhythmia
  • Hypoxic adaptation
  • Opioid peptides
  • Opioid receptors

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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