Antiarrhythmic and proarrhythmic properties of σ-receptor ligands

Yu B. Lishmanov, L. N. Maslov, A. V. Krylatov, D. S. Ugdyzhekova, P. Giligan, S. T. Tam

Research output: Contribution to journalArticle

Abstract

It has been found that the σ1- and σ3-receptor antagonists, DuP 734 intraperitoneally and XJ 448 intravenously, had antiarrhythmic effects against epinephrine-induced arrhythmias in rats. The ED50 for antiarrhythmic effect of DuP 734 was 0.157 mg/kg after intraperitoneal administration. Other σ-receptor antagonists (rimcazole, BMY 14802, haloperidol) did not affect the incidence of epinephrine-induced arrhythmias. σ1-Receptor agonists (DTG, N-allyl-normetazocine, (+)-3-PPP, (-)-3-PPP) had proarrhythmic effect after systemic administration. The σ-agonist N-allyl-normetazocine and σ-antagonist XJ 488 had no effect on the incidence of epinephrine-induced arrhythmias after intracerebroventricular administration. Therefore, it appears that the central nervous system does not play a significant role in the antiarrhythmic or proarrhythmic effects of σ-ligands. We hypothesize that these effects of σ-ligands might be dependent on their action on cardiac σ-receptors.

Original languageEnglish
Pages (from-to)43
Number of pages1
JournalEksperimental'naya i Klinicheskaya Farmakologiya
Volume63
Issue number2
Publication statusPublished - 2000

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Epinephrine
Cardiac Arrhythmias
Ligands
Incidence
Neurology
Haloperidol
Rats
Central Nervous System
normetazocine
DuP 734
alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol
rimcazole
preclamol

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Lishmanov, Y. B., Maslov, L. N., Krylatov, A. V., Ugdyzhekova, D. S., Giligan, P., & Tam, S. T. (2000). Antiarrhythmic and proarrhythmic properties of σ-receptor ligands. Eksperimental'naya i Klinicheskaya Farmakologiya, 63(2), 43.

Antiarrhythmic and proarrhythmic properties of σ-receptor ligands. / Lishmanov, Yu B.; Maslov, L. N.; Krylatov, A. V.; Ugdyzhekova, D. S.; Giligan, P.; Tam, S. T.

In: Eksperimental'naya i Klinicheskaya Farmakologiya, Vol. 63, No. 2, 2000, p. 43.

Research output: Contribution to journalArticle

Lishmanov, YB, Maslov, LN, Krylatov, AV, Ugdyzhekova, DS, Giligan, P & Tam, ST 2000, 'Antiarrhythmic and proarrhythmic properties of σ-receptor ligands', Eksperimental'naya i Klinicheskaya Farmakologiya, vol. 63, no. 2, pp. 43.
Lishmanov, Yu B. ; Maslov, L. N. ; Krylatov, A. V. ; Ugdyzhekova, D. S. ; Giligan, P. ; Tam, S. T. / Antiarrhythmic and proarrhythmic properties of σ-receptor ligands. In: Eksperimental'naya i Klinicheskaya Farmakologiya. 2000 ; Vol. 63, No. 2. pp. 43.
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