The antiopioid peptide nociceptin does not affect heart resistance to the proarrhythmic effect of epinephrine or calcium chloride, but it produces an antiarrhythmic effect in the aconitine arrhythmia model. Nociceptin prolongs the QRS interval and does not affect heart rate and duration of the RQ interval. The antiarrhythmic effect of nociceptin is not related to changes in the tone of the autonomic nervous system. Nociceptin is supposed to block fast Na+ channels in cardiomyocytes.
|Number of pages||3|
|Journal||Bulletin of Experimental Biology and Medicine|
|Publication status||Published - Dec 1998|
- Fast Na channels
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)