Antiarrhythmic activity of the antiopioid peptide nociceptin and its effect on the fast Na+ channels in cardiomyocytes

Yu B. Lishmanov, A. V. Krylatov, L. N. Maslov

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The antiopioid peptide nociceptin does not affect heart resistance to the proarrhythmic effect of epinephrine or calcium chloride, but it produces an antiarrhythmic effect in the aconitine arrhythmia model. Nociceptin prolongs the QRS interval and does not affect heart rate and duration of the RQ interval. The antiarrhythmic effect of nociceptin is not related to changes in the tone of the autonomic nervous system. Nociceptin is supposed to block fast Na+ channels in cardiomyocytes.

Original languageEnglish
Pages (from-to)1224-1226
Number of pages3
JournalBulletin of Experimental Biology and Medicine
Volume126
Issue number12
Publication statusPublished - Dec 1998

Keywords

  • Arrhythmias
  • Fast Na channels
  • Nociceptin

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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