Antiarrhythmic activity of agonists of peripheral μ-opiate receptors

L. N. Maslov, A. V. Krylatov, Yu B. Lishmanov

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

It was shown that the agonists of peripheral μ-receptors DALBA and PLO17 increase the resistance of the heart to adrenaline, aconitine, ischemic, reperfusion, and CaCl2-induced arrhythmias and also raise the threshold of ventricular fibrillation in postinfarction cardiosclerosis. The antagonists of μ-receptors naloxon and STAR removed these effects. The ganglion-blocking agent hexamethonium had no influence on the antiarrhythmic effect of DALBA. It is supposed that the autonomic nervous system does not play any essential role in the mechanism of the antiarrhythmic effect of agonists of peripheral μ-receptors.

Original languageEnglish
Pages (from-to)31
Number of pages1
JournalEksperimental'naya i Klinicheskaya Farmakologiya
Volume62
Issue number3
Publication statusPublished - 1999

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Aconitine
Hexamethonium
Autonomic Nervous System
Neurology
Opioid Receptors
Ventricular Fibrillation
Ganglia
Epinephrine
Reperfusion
Cardiac Arrhythmias

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Antiarrhythmic activity of agonists of peripheral μ-opiate receptors. / Maslov, L. N.; Krylatov, A. V.; Lishmanov, Yu B.

In: Eksperimental'naya i Klinicheskaya Farmakologiya, Vol. 62, No. 3, 1999, p. 31.

Research output: Contribution to journalArticle

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