Abstract
It was shown that the agonists of peripheral μ-receptors DALBA and PLO17 increase the resistance of the heart to adrenaline, aconitine, ischemic, reperfusion, and CaCl2-induced arrhythmias and also raise the threshold of ventricular fibrillation in postinfarction cardiosclerosis. The antagonists of μ-receptors naloxon and STAR removed these effects. The ganglion-blocking agent hexamethonium had no influence on the antiarrhythmic effect of DALBA. It is supposed that the autonomic nervous system does not play any essential role in the mechanism of the antiarrhythmic effect of agonists of peripheral μ-receptors.
| Original language | English |
|---|---|
| Pages (from-to) | 31 |
| Number of pages | 1 |
| Journal | Eksperimental'naya i Klinicheskaya Farmakologiya |
| Volume | 62 |
| Issue number | 3 |
| Publication status | Published - 1999 |
Fingerprint
ASJC Scopus subject areas
- Pharmacology, Toxicology and Pharmaceutics(all)
Cite this
Antiarrhythmic activity of agonists of peripheral μ-opiate receptors. / Maslov, L. N.; Krylatov, A. V.; Lishmanov, Yu B.
In: Eksperimental'naya i Klinicheskaya Farmakologiya, Vol. 62, No. 3, 1999, p. 31.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Antiarrhythmic activity of agonists of peripheral μ-opiate receptors
AU - Maslov, L. N.
AU - Krylatov, A. V.
AU - Lishmanov, Yu B.
PY - 1999
Y1 - 1999
N2 - It was shown that the agonists of peripheral μ-receptors DALBA and PLO17 increase the resistance of the heart to adrenaline, aconitine, ischemic, reperfusion, and CaCl2-induced arrhythmias and also raise the threshold of ventricular fibrillation in postinfarction cardiosclerosis. The antagonists of μ-receptors naloxon and STAR removed these effects. The ganglion-blocking agent hexamethonium had no influence on the antiarrhythmic effect of DALBA. It is supposed that the autonomic nervous system does not play any essential role in the mechanism of the antiarrhythmic effect of agonists of peripheral μ-receptors.
AB - It was shown that the agonists of peripheral μ-receptors DALBA and PLO17 increase the resistance of the heart to adrenaline, aconitine, ischemic, reperfusion, and CaCl2-induced arrhythmias and also raise the threshold of ventricular fibrillation in postinfarction cardiosclerosis. The antagonists of μ-receptors naloxon and STAR removed these effects. The ganglion-blocking agent hexamethonium had no influence on the antiarrhythmic effect of DALBA. It is supposed that the autonomic nervous system does not play any essential role in the mechanism of the antiarrhythmic effect of agonists of peripheral μ-receptors.
UR - http://www.scopus.com/inward/record.url?scp=0041728499&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0041728499&partnerID=8YFLogxK
M3 - Article
VL - 62
SP - 31
JO - Eksperimental'naya i Klinicheskaya Farmakologiya
JF - Eksperimental'naya i Klinicheskaya Farmakologiya
SN - 0869-2092
IS - 3
ER -