Antiarrhythmic activity of agonists of peripheral μ-opiate receptors

Abstract

It was shown that the agonists of peripheral μ-receptors DALBA and PLO17 increase the resistance of the heart to adrenaline, aconitine, ischemic, reperfusion, and CaCl₂-induced arrhythmias and also raise the threshold of ventricular fibrillation in postinfarction cardiosclerosis. The antagonists of μ-receptors naloxon and STAR removed these effects. The ganglion-blocking agent hexamethonium had no influence on the antiarrhythmic effect of DALBA. It is supposed that the autonomic nervous system does not play any essential role in the mechanism of the antiarrhythmic effect of agonists of peripheral μ-receptors.

Original language	English
Pages (from-to)	31
Number of pages	1
Journal	Eksperimental'naya i Klinicheskaya Farmakologiya
Volume	62
Issue number	3
Publication status	Published - 1999

ASJC Scopus subject areas

Pharmacology, Toxicology and Pharmaceutics(all)

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title = "Antiarrhythmic activity of agonists of peripheral μ-opiate receptors",

abstract = "It was shown that the agonists of peripheral μ-receptors DALBA and PLO17 increase the resistance of the heart to adrenaline, aconitine, ischemic, reperfusion, and CaCl2-induced arrhythmias and also raise the threshold of ventricular fibrillation in postinfarction cardiosclerosis. The antagonists of μ-receptors naloxon and STAR removed these effects. The ganglion-blocking agent hexamethonium had no influence on the antiarrhythmic effect of DALBA. It is supposed that the autonomic nervous system does not play any essential role in the mechanism of the antiarrhythmic effect of agonists of peripheral μ-receptors.",

author = "Maslov, {L. N.} and Krylatov, {A. V.} and Lishmanov, {Yu B.}",

year = "1999",

language = "English",

volume = "62",

pages = "31",

journal = "Eksperimental'naya i Klinicheskaya Farmakologiya",

issn = "0869-2092",

publisher = "Izdatelstvo Meditsina",

number = "3",

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T1 - Antiarrhythmic activity of agonists of peripheral μ-opiate receptors

AU - Maslov, L. N.

AU - Krylatov, A. V.

AU - Lishmanov, Yu B.

PY - 1999

Y1 - 1999

N2 - It was shown that the agonists of peripheral μ-receptors DALBA and PLO17 increase the resistance of the heart to adrenaline, aconitine, ischemic, reperfusion, and CaCl2-induced arrhythmias and also raise the threshold of ventricular fibrillation in postinfarction cardiosclerosis. The antagonists of μ-receptors naloxon and STAR removed these effects. The ganglion-blocking agent hexamethonium had no influence on the antiarrhythmic effect of DALBA. It is supposed that the autonomic nervous system does not play any essential role in the mechanism of the antiarrhythmic effect of agonists of peripheral μ-receptors.

AB - It was shown that the agonists of peripheral μ-receptors DALBA and PLO17 increase the resistance of the heart to adrenaline, aconitine, ischemic, reperfusion, and CaCl2-induced arrhythmias and also raise the threshold of ventricular fibrillation in postinfarction cardiosclerosis. The antagonists of μ-receptors naloxon and STAR removed these effects. The ganglion-blocking agent hexamethonium had no influence on the antiarrhythmic effect of DALBA. It is supposed that the autonomic nervous system does not play any essential role in the mechanism of the antiarrhythmic effect of agonists of peripheral μ-receptors.

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VL - 62

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