ANTI-INFLAMMATORY ACTIVITY OF SODIUM SALT OF 4-(O-β-D-GLUCOPYRANOSYLOXY)BENZOIC ACID

T. O. Murashko, I. V. Simirnov, A. A. Bondarev, A. A. Ivanov, P. S. Postnikov, A. O. Nemtsev, V. V. Udut

Research output: Contribution to journalArticle

Abstract

We have evaluated the anti-inflammatory activity of the sodium salt of 4-(O-β-D-glucopyranosyloxy)benzoic acid in comparison to well-known nonsteroidal anti-inflammatory drugs (NSAIDs). Carrageenan suspension (1%, 0.1 mL) was injected into subplantar region of the right hindpaw of rats (n = 12) pretreated (7 days and 60 min before carrageenan injection) intragastrically with methyl ester of 4(β-D-glucopyranosyloxy)benzoic acid (20 mg/kg), acetylsalicylic acid (20 mg/kg), 4-hydroxybenzoic acid (20 mg/kg), or vehicle (2 mL of purified water). Paw edema volume was measured plethysmographically at 1, 2 and 4 h after carrageenan injection. The results showed that intragastric administration of the sodium salt of 4-(O-β-D-glucopyranosyloxy)benzoic acid in a dose of 20 mg/kg for 7 days decreased the intensity of experimental inflammation.

Original languageEnglish
Pages (from-to)26-28
Number of pages3
JournalEksperimental'naia i klinicheskaia farmakologiia
Volume79
Issue number4
Publication statusPublished - 1 Aug 2016

Fingerprint

Benzoic Acid
Carrageenan
Anti-Inflammatory Agents
Salts
Sodium
Injections
Aspirin
Rats
Edema
Suspensions
Esters
Inflammation
Water
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

Cite this

ANTI-INFLAMMATORY ACTIVITY OF SODIUM SALT OF 4-(O-β-D-GLUCOPYRANOSYLOXY)BENZOIC ACID. / Murashko, T. O.; Simirnov, I. V.; Bondarev, A. A.; Ivanov, A. A.; Postnikov, P. S.; Nemtsev, A. O.; Udut, V. V.

In: Eksperimental'naia i klinicheskaia farmakologiia, Vol. 79, No. 4, 01.08.2016, p. 26-28.

Research output: Contribution to journalArticle

Murashko, T. O. ; Simirnov, I. V. ; Bondarev, A. A. ; Ivanov, A. A. ; Postnikov, P. S. ; Nemtsev, A. O. ; Udut, V. V. / ANTI-INFLAMMATORY ACTIVITY OF SODIUM SALT OF 4-(O-β-D-GLUCOPYRANOSYLOXY)BENZOIC ACID. In: Eksperimental'naia i klinicheskaia farmakologiia. 2016 ; Vol. 79, No. 4. pp. 26-28.
@article{2fa4c94c346c474387bcd909ee0afe56,
title = "ANTI-INFLAMMATORY ACTIVITY OF SODIUM SALT OF 4-(O-β-D-GLUCOPYRANOSYLOXY)BENZOIC ACID",
abstract = "We have evaluated the anti-inflammatory activity of the sodium salt of 4-(O-β-D-glucopyranosyloxy)benzoic acid in comparison to well-known nonsteroidal anti-inflammatory drugs (NSAIDs). Carrageenan suspension (1{\%}, 0.1 mL) was injected into subplantar region of the right hindpaw of rats (n = 12) pretreated (7 days and 60 min before carrageenan injection) intragastrically with methyl ester of 4(β-D-glucopyranosyloxy)benzoic acid (20 mg/kg), acetylsalicylic acid (20 mg/kg), 4-hydroxybenzoic acid (20 mg/kg), or vehicle (2 mL of purified water). Paw edema volume was measured plethysmographically at 1, 2 and 4 h after carrageenan injection. The results showed that intragastric administration of the sodium salt of 4-(O-β-D-glucopyranosyloxy)benzoic acid in a dose of 20 mg/kg for 7 days decreased the intensity of experimental inflammation.",
author = "Murashko, {T. O.} and Simirnov, {I. V.} and Bondarev, {A. A.} and Ivanov, {A. A.} and Postnikov, {P. S.} and Nemtsev, {A. O.} and Udut, {V. V.}",
year = "2016",
month = "8",
day = "1",
language = "English",
volume = "79",
pages = "26--28",
journal = "Eksperimental'naya i Klinicheskaya Farmakologiya",
issn = "0869-2092",
publisher = "Izdatelstvo Meditsina",
number = "4",

}

TY - JOUR

T1 - ANTI-INFLAMMATORY ACTIVITY OF SODIUM SALT OF 4-(O-β-D-GLUCOPYRANOSYLOXY)BENZOIC ACID

AU - Murashko, T. O.

AU - Simirnov, I. V.

AU - Bondarev, A. A.

AU - Ivanov, A. A.

AU - Postnikov, P. S.

AU - Nemtsev, A. O.

AU - Udut, V. V.

PY - 2016/8/1

Y1 - 2016/8/1

N2 - We have evaluated the anti-inflammatory activity of the sodium salt of 4-(O-β-D-glucopyranosyloxy)benzoic acid in comparison to well-known nonsteroidal anti-inflammatory drugs (NSAIDs). Carrageenan suspension (1%, 0.1 mL) was injected into subplantar region of the right hindpaw of rats (n = 12) pretreated (7 days and 60 min before carrageenan injection) intragastrically with methyl ester of 4(β-D-glucopyranosyloxy)benzoic acid (20 mg/kg), acetylsalicylic acid (20 mg/kg), 4-hydroxybenzoic acid (20 mg/kg), or vehicle (2 mL of purified water). Paw edema volume was measured plethysmographically at 1, 2 and 4 h after carrageenan injection. The results showed that intragastric administration of the sodium salt of 4-(O-β-D-glucopyranosyloxy)benzoic acid in a dose of 20 mg/kg for 7 days decreased the intensity of experimental inflammation.

AB - We have evaluated the anti-inflammatory activity of the sodium salt of 4-(O-β-D-glucopyranosyloxy)benzoic acid in comparison to well-known nonsteroidal anti-inflammatory drugs (NSAIDs). Carrageenan suspension (1%, 0.1 mL) was injected into subplantar region of the right hindpaw of rats (n = 12) pretreated (7 days and 60 min before carrageenan injection) intragastrically with methyl ester of 4(β-D-glucopyranosyloxy)benzoic acid (20 mg/kg), acetylsalicylic acid (20 mg/kg), 4-hydroxybenzoic acid (20 mg/kg), or vehicle (2 mL of purified water). Paw edema volume was measured plethysmographically at 1, 2 and 4 h after carrageenan injection. The results showed that intragastric administration of the sodium salt of 4-(O-β-D-glucopyranosyloxy)benzoic acid in a dose of 20 mg/kg for 7 days decreased the intensity of experimental inflammation.

UR - http://www.scopus.com/inward/record.url?scp=84984706163&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84984706163&partnerID=8YFLogxK

M3 - Article

VL - 79

SP - 26

EP - 28

JO - Eksperimental'naya i Klinicheskaya Farmakologiya

JF - Eksperimental'naya i Klinicheskaya Farmakologiya

SN - 0869-2092

IS - 4

ER -