ANTI-INFLAMMATORY ACTIVITY OF SODIUM SALT OF 4-(O-β-D-GLUCOPYRANOSYLOXY)BENZOIC ACID

T. O. Murashko, I. V. Simirnov, A. A. Bondarev, A. A. Ivanov, P. S. Postnikov, A. O. Nemtsev, V. V. Udut

Research output: Contribution to journalArticle

Abstract

We have evaluated the anti-inflammatory activity of the sodium salt of 4-(O-β-D-glucopyranosyloxy)benzoic acid in comparison to well-known nonsteroidal anti-inflammatory drugs (NSAIDs). Carrageenan suspension (1%, 0.1 mL) was injected into subplantar region of the right hindpaw of rats (n = 12) pretreated (7 days and 60 min before carrageenan injection) intragastrically with methyl ester of 4(β-D-glucopyranosyloxy)benzoic acid (20 mg/kg), acetylsalicylic acid (20 mg/kg), 4-hydroxybenzoic acid (20 mg/kg), or vehicle (2 mL of purified water). Paw edema volume was measured plethysmographically at 1, 2 and 4 h after carrageenan injection. The results showed that intragastric administration of the sodium salt of 4-(O-β-D-glucopyranosyloxy)benzoic acid in a dose of 20 mg/kg for 7 days decreased the intensity of experimental inflammation.

Original languageEnglish
Pages (from-to)26-28
Number of pages3
JournalEksperimental'naia i klinicheskaia farmakologiia
Volume79
Issue number4
Publication statusPublished - 1 Aug 2016

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

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