Anti-inflammatory activity of sodium salt of 4-(0-β-d-gluc0pyran0syl0xy)benz0ic acid

T. O. Murashko, I. V. Smirnov, A. A. Bondarev, A. A. Ivanov, P. S. Postnikov, A. O. Nemtsev, V. V. Udut

Research output: Contribution to journalArticle

Abstract

We have evaluated the anti-inflammatory activity of the sodium salt of 4-(0-β-D-glucopyranosyloxy)benzoic acid in comparison to well-known nonsteroidal anti-inflammatory drugs (NSAIDs). Carragcenan suspension (1%, 0.1 mL) was injected into subplantar region of the right hindpaw of rats (n - 12) pretreated (7 days and 60 min before carrageenan injection) intragastrically with methyl ester of 4(β-D-glucopyranosyloxy)benzoic acid (20 mg/kg), acetylsalicylic acid (20 mg/kg), 4-hydroxy benzoic acid (20 mg/kg), or vehicle (2 mL of purified water). Paw edema volume was measured plethysmographically at 1,2 and 4 h after carrageenan injection. The results showed that intragastric administration of the sodium salt of 4-(0-β-D-glucopyranosyIoxy)benzoic acid in a dose of 20 mg/kg for 7 days decreased the intensity of experimental inflammation.

Original languageEnglish
Pages (from-to)26-28
Number of pages3
JournalEksperimental'naya i Klinicheskaya Farmakologiya
Volume79
Issue number4
Publication statusPublished - 1 Jan 2016

Fingerprint

Benzoic Acid
Anti-Inflammatory Agents
Salts
Sodium
Acids
Carrageenan
Injections
Aspirin
Rats
Edema
Suspensions
Esters
Inflammation
Water
Pharmaceutical Preparations

Keywords

  • Diuretics
  • Innovative drug
  • NSAIDs
  • Phenol glycoside
  • Rats

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

Cite this

Anti-inflammatory activity of sodium salt of 4-(0-β-d-gluc0pyran0syl0xy)benz0ic acid. / Murashko, T. O.; Smirnov, I. V.; Bondarev, A. A.; Ivanov, A. A.; Postnikov, P. S.; Nemtsev, A. O.; Udut, V. V.

In: Eksperimental'naya i Klinicheskaya Farmakologiya, Vol. 79, No. 4, 01.01.2016, p. 26-28.

Research output: Contribution to journalArticle

Murashko, T. O. ; Smirnov, I. V. ; Bondarev, A. A. ; Ivanov, A. A. ; Postnikov, P. S. ; Nemtsev, A. O. ; Udut, V. V. / Anti-inflammatory activity of sodium salt of 4-(0-β-d-gluc0pyran0syl0xy)benz0ic acid. In: Eksperimental'naya i Klinicheskaya Farmakologiya. 2016 ; Vol. 79, No. 4. pp. 26-28.
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