Analysis of Mechanisms of Interaction between Ciprofloxacin-Based Radiopharmaceutical Labeled with Technetium-99m and Cultured Staphylococcus aureus

Abstract

Mechanisms of interaction between ciprofloxacin-based radiopharmaceutical labeled with technetium-99m and cultured Staphylococcus aureus were studied. The substance, reagent for radiopharmaceutical, and the radiopharmaceutical demonstrated similar bactericidal activity against the test bacterial cultures, which confi rmed specifi c antibacterial activity of technetium-99m-labeled ciprofloxacin. The technetium-99m-labeled antibiotic reversibly interacts with inactivated Staphylococcus aureus culture, which indicates the existence of an additional non-specific pathway for radiopharmaceutical accumulation in the bacterial inflammation focus. Our experiment ruled out the possibility of binding free technetium-99m at concentrations <5% (its concentration in the radiopharmaceutical) with Staphylococcus aureus.

Original language	English
Pages (from-to)	732-734
Number of pages	3
Journal	Bulletin of Experimental Biology and Medicine
Volume	157
Issue number	6
DOIs	https://doi.org/10.1007/s10517-014-2654-2
Publication status	Published - 31 Oct 2014

Keywords

ciprofloxacin
inflammation
technetium-99m

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

Access to Document

10.1007/s10517-014-2654-2

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Analysis of Mechanisms of Interaction between Ciprofloxacin-Based Radiopharmaceutical Labeled with Technetium-99m and Cultured Staphylococcus aureus. / Sazonova, Svetlana Ivanovna; Karpova, M. R.; Il’yushenkova, Yu N.; Varlamova, Natalia Valerievna ; Lishmanov, Yu B.

In: Bulletin of Experimental Biology and Medicine, Vol. 157, No. 6, 31.10.2014, p. 732-734.

Research output: Contribution to journal › Article › peer-review

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abstract = "Mechanisms of interaction between ciprofloxacin-based radiopharmaceutical labeled with technetium-99m and cultured Staphylococcus aureus were studied. The substance, reagent for radiopharmaceutical, and the radiopharmaceutical demonstrated similar bactericidal activity against the test bacterial cultures, which confi rmed specifi c antibacterial activity of technetium-99m-labeled ciprofloxacin. The technetium-99m-labeled antibiotic reversibly interacts with inactivated Staphylococcus aureus culture, which indicates the existence of an additional non-specific pathway for radiopharmaceutical accumulation in the bacterial inflammation focus. Our experiment ruled out the possibility of binding free technetium-99m at concentrations <5% (its concentration in the radiopharmaceutical) with Staphylococcus aureus.",

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author = "Svetlana Ivanovna Sazonova and Karpova, {M. R.} and Il{\textquoteright}yushenkova, {Yu N.} and Natalia Valerievna Varlamova and Lishmanov, {Yu B.}",

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AU - Il’yushenkova, Yu N.

AU - Varlamova, Natalia Valerievna

AU - Lishmanov, Yu B.

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