Analysis of Mechanisms of Interaction between Ciprofloxacin-Based Radiopharmaceutical Labeled with Technetium-99m and Cultured Staphylococcus aureus

Svetlana Ivanovna Sazonova, M. R. Karpova, Yu N. Il’yushenkova, Natalia Valerievna Varlamova, Yu B. Lishmanov

Research output: Contribution to journalArticle

Abstract

Mechanisms of interaction between ciprofloxacin-based radiopharmaceutical labeled with technetium-99m and cultured Staphylococcus aureus were studied. The substance, reagent for radiopharmaceutical, and the radiopharmaceutical demonstrated similar bactericidal activity against the test bacterial cultures, which confi rmed specifi c antibacterial activity of technetium-99m-labeled ciprofloxacin. The technetium-99m-labeled antibiotic reversibly interacts with inactivated Staphylococcus aureus culture, which indicates the existence of an additional non-specific pathway for radiopharmaceutical accumulation in the bacterial inflammation focus. Our experiment ruled out the possibility of binding free technetium-99m at concentrations <5% (its concentration in the radiopharmaceutical) with Staphylococcus aureus.

Original languageEnglish
Pages (from-to)732-734
Number of pages3
JournalBulletin of Experimental Biology and Medicine
Volume157
Issue number6
DOIs
Publication statusPublished - 31 Oct 2014

Keywords

  • ciprofloxacin
  • inflammation
  • technetium-99m

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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