Abstract
Mechanisms of interaction between ciprofloxacin-based radiopharmaceutical labeled with technetium-99m and cultured Staphylococcus aureus were studied. The substance, reagent for radiopharmaceutical, and the radiopharmaceutical demonstrated similar bactericidal activity against the test bacterial cultures, which confi rmed specifi c antibacterial activity of technetium-99m-labeled ciprofloxacin. The technetium-99m-labeled antibiotic reversibly interacts with inactivated Staphylococcus aureus culture, which indicates the existence of an additional non-specific pathway for radiopharmaceutical accumulation in the bacterial inflammation focus. Our experiment ruled out the possibility of binding free technetium-99m at concentrations <5% (its concentration in the radiopharmaceutical) with Staphylococcus aureus.
| Original language | English |
|---|---|
| Pages (from-to) | 732-734 |
| Number of pages | 3 |
| Journal | Bulletin of Experimental Biology and Medicine |
| Volume | 157 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 31 Oct 2014 |
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Keywords
- ciprofloxacin
- inflammation
- technetium-99m
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Analysis of Mechanisms of Interaction between Ciprofloxacin-Based Radiopharmaceutical Labeled with Technetium-99m and Cultured Staphylococcus aureus. / Sazonova, Svetlana Ivanovna; Karpova, M. R.; Il’yushenkova, Yu N.; Varlamova, Natalia Valerievna; Lishmanov, Yu B.
In: Bulletin of Experimental Biology and Medicine, Vol. 157, No. 6, 31.10.2014, p. 732-734.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Analysis of Mechanisms of Interaction between Ciprofloxacin-Based Radiopharmaceutical Labeled with Technetium-99m and Cultured Staphylococcus aureus
AU - Sazonova, Svetlana Ivanovna
AU - Karpova, M. R.
AU - Il’yushenkova, Yu N.
AU - Varlamova, Natalia Valerievna
AU - Lishmanov, Yu B.
PY - 2014/10/31
Y1 - 2014/10/31
N2 - Mechanisms of interaction between ciprofloxacin-based radiopharmaceutical labeled with technetium-99m and cultured Staphylococcus aureus were studied. The substance, reagent for radiopharmaceutical, and the radiopharmaceutical demonstrated similar bactericidal activity against the test bacterial cultures, which confi rmed specifi c antibacterial activity of technetium-99m-labeled ciprofloxacin. The technetium-99m-labeled antibiotic reversibly interacts with inactivated Staphylococcus aureus culture, which indicates the existence of an additional non-specific pathway for radiopharmaceutical accumulation in the bacterial inflammation focus. Our experiment ruled out the possibility of binding free technetium-99m at concentrations <5% (its concentration in the radiopharmaceutical) with Staphylococcus aureus.
AB - Mechanisms of interaction between ciprofloxacin-based radiopharmaceutical labeled with technetium-99m and cultured Staphylococcus aureus were studied. The substance, reagent for radiopharmaceutical, and the radiopharmaceutical demonstrated similar bactericidal activity against the test bacterial cultures, which confi rmed specifi c antibacterial activity of technetium-99m-labeled ciprofloxacin. The technetium-99m-labeled antibiotic reversibly interacts with inactivated Staphylococcus aureus culture, which indicates the existence of an additional non-specific pathway for radiopharmaceutical accumulation in the bacterial inflammation focus. Our experiment ruled out the possibility of binding free technetium-99m at concentrations <5% (its concentration in the radiopharmaceutical) with Staphylococcus aureus.
KW - ciprofloxacin
KW - inflammation
KW - technetium-99m
UR - http://www.scopus.com/inward/record.url?scp=84922083297&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84922083297&partnerID=8YFLogxK
U2 - 10.1007/s10517-014-2654-2
DO - 10.1007/s10517-014-2654-2
M3 - Article
C2 - 25342481
AN - SCOPUS:84922083297
VL - 157
SP - 732
EP - 734
JO - Bulletin of Experimental Biology and Medicine
JF - Bulletin of Experimental Biology and Medicine
SN - 0007-4888
IS - 6
ER -