Abstract
A number of relatively volatile acetylenes RC ≡ CH (R = aryl or hetaryl) have been prepared with high yields by heating a mixture of the corresponding alcohols RC ≡ CC(CH3)2OH and paraffin oil with small amounts of powdered potassium hydroxide in vacuum. The alcohols were obtained by Pd/Cu-catalyzed cross coupling of aryl or hetaryl halides RX (X = Br, in one case I) with the commercially available HC ≡ CC(CH3)2OH.
| Original language | English |
|---|---|
| Pages (from-to) | 589-590 |
| Number of pages | 2 |
| Journal | Synthesis |
| Issue number | 5 |
| Publication status | Published - 1 Jan 1996 |
| Externally published | Yes |
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Keywords
- acetylenic alcohols
- hetarylacetylenes
- KOH-catalyzed elimination of acetone
- retro-Favorsky reaction
- synthesis of 2-iodo-1-methylpyrrole
ASJC Scopus subject areas
- Catalysis
- Organic Chemistry
Cite this
An improved procedure for the preparation of aryl- and hetarylacetylenes. / Mal'Kina, A. G.; Brandsma, L.; Vasilevsky, S. F.; Trofimov, B. A.
In: Synthesis, No. 5, 01.01.1996, p. 589-590.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - An improved procedure for the preparation of aryl- and hetarylacetylenes
AU - Mal'Kina, A. G.
AU - Brandsma, L.
AU - Vasilevsky, S. F.
AU - Trofimov, B. A.
PY - 1996/1/1
Y1 - 1996/1/1
N2 - A number of relatively volatile acetylenes RC ≡ CH (R = aryl or hetaryl) have been prepared with high yields by heating a mixture of the corresponding alcohols RC ≡ CC(CH3)2OH and paraffin oil with small amounts of powdered potassium hydroxide in vacuum. The alcohols were obtained by Pd/Cu-catalyzed cross coupling of aryl or hetaryl halides RX (X = Br, in one case I) with the commercially available HC ≡ CC(CH3)2OH.
AB - A number of relatively volatile acetylenes RC ≡ CH (R = aryl or hetaryl) have been prepared with high yields by heating a mixture of the corresponding alcohols RC ≡ CC(CH3)2OH and paraffin oil with small amounts of powdered potassium hydroxide in vacuum. The alcohols were obtained by Pd/Cu-catalyzed cross coupling of aryl or hetaryl halides RX (X = Br, in one case I) with the commercially available HC ≡ CC(CH3)2OH.
KW - acetylenic alcohols
KW - hetarylacetylenes
KW - KOH-catalyzed elimination of acetone
KW - retro-Favorsky reaction
KW - synthesis of 2-iodo-1-methylpyrrole
UR - http://www.scopus.com/inward/record.url?scp=0029955629&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029955629&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0029955629
SP - 589
EP - 590
JO - Synthesis
JF - Synthesis
SN - 0039-7881
IS - 5
ER -