Abstract
A number of relatively volatile acetylenes RC ≡ CH (R = aryl or hetaryl) have been prepared with high yields by heating a mixture of the corresponding alcohols RC ≡ CC(CH3)2OH and paraffin oil with small amounts of powdered potassium hydroxide in vacuum. The alcohols were obtained by Pd/Cu-catalyzed cross coupling of aryl or hetaryl halides RX (X = Br, in one case I) with the commercially available HC ≡ CC(CH3)2OH.
Original language | English |
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Pages (from-to) | 589-590 |
Number of pages | 2 |
Journal | Synthesis |
Issue number | 5 |
Publication status | Published - 1 Jan 1996 |
Externally published | Yes |
Keywords
- acetylenic alcohols
- hetarylacetylenes
- KOH-catalyzed elimination of acetone
- retro-Favorsky reaction
- synthesis of 2-iodo-1-methylpyrrole
ASJC Scopus subject areas
- Catalysis
- Organic Chemistry