Abstract
A number of relatively volatile acetylenes RC ≡ CH (R = aryl or hetaryl) have been prepared with high yields by heating a mixture of the corresponding alcohols RC ≡ CC(CH3)2OH and paraffin oil with small amounts of powdered potassium hydroxide in vacuum. The alcohols were obtained by Pd/Cu-catalyzed cross coupling of aryl or hetaryl halides RX (X = Br, in one case I) with the commercially available HC ≡ CC(CH3)2OH.
| Original language | English |
|---|---|
| Pages (from-to) | 589-590 |
| Number of pages | 2 |
| Journal | Synthesis |
| Issue number | 5 |
| Publication status | Published - 1 Jan 1996 |
| Externally published | Yes |
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Keywords
- acetylenic alcohols
- hetarylacetylenes
- KOH-catalyzed elimination of acetone
- retro-Favorsky reaction
- synthesis of 2-iodo-1-methylpyrrole
ASJC Scopus subject areas
- Catalysis
- Organic Chemistry
Cite this
Mal'Kina, A. G., Brandsma, L., Vasilevsky, S. F., & Trofimov, B. A. (1996). An improved procedure for the preparation of aryl- and hetarylacetylenes. Synthesis, (5), 589-590.