An improved procedure for the preparation of aryl- and hetarylacetylenes

A. G. Mal'Kina, L. Brandsma, S. F. Vasilevsky, B. A. Trofimov

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

A number of relatively volatile acetylenes RC ≡ CH (R = aryl or hetaryl) have been prepared with high yields by heating a mixture of the corresponding alcohols RC ≡ CC(CH3)2OH and paraffin oil with small amounts of powdered potassium hydroxide in vacuum. The alcohols were obtained by Pd/Cu-catalyzed cross coupling of aryl or hetaryl halides RX (X = Br, in one case I) with the commercially available HC ≡ CC(CH3)2OH.

Original languageEnglish
Pages (from-to)589-590
Number of pages2
JournalSynthesis
Issue number5
Publication statusPublished - 1 Jan 1996
Externally publishedYes

    Fingerprint

Keywords

  • acetylenic alcohols
  • hetarylacetylenes
  • KOH-catalyzed elimination of acetone
  • retro-Favorsky reaction
  • synthesis of 2-iodo-1-methylpyrrole

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

Cite this

Mal'Kina, A. G., Brandsma, L., Vasilevsky, S. F., & Trofimov, B. A. (1996). An improved procedure for the preparation of aryl- and hetarylacetylenes. Synthesis, (5), 589-590.