An expeditious and environmentally benign preparation of aryl halides from aryl amines by solvent-free grinding

Abstract

An efficient solvent-free methodology for conversion of various aryl amines into bromides and chlorides via arenediazonium tosylate salts under grinding conditions is disclosed. This new methodology not only avoids the use of strong acids and expensive reagents for diazotization-halogenation reactions, but also decreases the amount of organic waste from the reaction process.

Original language	English
Pages (from-to)	6769-6771
Number of pages	3
Journal	Tetrahedron Letters
Volume	51
Issue number	51
DOIs	https://doi.org/10.1016/j.tetlet.2010.10.099
Publication status	Published - 22 Dec 2010

Keywords

Arenediazonium tosylate salt
Halogenation
Solvent-free grinding

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2010.10.099

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Moon, M. E., Choi, Y., Lee, Y. M., Vajpayee, V., Trusova, M., Filimonov, V. D., & Chi, K. W. (2010). An expeditious and environmentally benign preparation of aryl halides from aryl amines by solvent-free grinding. Tetrahedron Letters, 51(51), 6769-6771. https://doi.org/10.1016/j.tetlet.2010.10.099

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abstract = "An efficient solvent-free methodology for conversion of various aryl amines into bromides and chlorides via arenediazonium tosylate salts under grinding conditions is disclosed. This new methodology not only avoids the use of strong acids and expensive reagents for diazotization-halogenation reactions, but also decreases the amount of organic waste from the reaction process.",

keywords = "Arenediazonium tosylate salt, Halogenation, Solvent-free grinding",

author = "Moon, {Mi Eun} and Younghwa Choi and Lee, {Young Min} and Vaishali Vajpayee and Marina Trusova and Filimonov, {Victor D.} and Chi, {Ki Whan}",

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T1 - An expeditious and environmentally benign preparation of aryl halides from aryl amines by solvent-free grinding

AU - Moon, Mi Eun

AU - Choi, Younghwa

AU - Lee, Young Min

AU - Vajpayee, Vaishali

AU - Trusova, Marina

AU - Filimonov, Victor D.

AU - Chi, Ki Whan

PY - 2010/12/22

Y1 - 2010/12/22

N2 - An efficient solvent-free methodology for conversion of various aryl amines into bromides and chlorides via arenediazonium tosylate salts under grinding conditions is disclosed. This new methodology not only avoids the use of strong acids and expensive reagents for diazotization-halogenation reactions, but also decreases the amount of organic waste from the reaction process.

AB - An efficient solvent-free methodology for conversion of various aryl amines into bromides and chlorides via arenediazonium tosylate salts under grinding conditions is disclosed. This new methodology not only avoids the use of strong acids and expensive reagents for diazotization-halogenation reactions, but also decreases the amount of organic waste from the reaction process.

KW - Arenediazonium tosylate salt

KW - Halogenation

KW - Solvent-free grinding

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

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