An expeditious and environmentally benign preparation of aryl halides from aryl amines by solvent-free grinding

Mi Eun Moon, Younghwa Choi, Young Min Lee, Vaishali Vajpayee, Marina Trusova, Victor D. Filimonov, Ki Whan Chi

Research output: Contribution to journal › Article

Abstract

An efficient solvent-free methodology for conversion of various aryl amines into bromides and chlorides via arenediazonium tosylate salts under grinding conditions is disclosed. This new methodology not only avoids the use of strong acids and expensive reagents for diazotization-halogenation reactions, but also decreases the amount of organic waste from the reaction process.

Original language	English
Pages (from-to)	6769-6771
Number of pages	3
Journal	Tetrahedron Letters
Volume	51
Issue number	51
DOIs	https://doi.org/10.1016/j.tetlet.2010.10.099
Publication status	Published - 22 Dec 2010

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Halogenation

Bromides

Amines

Chlorides

Salts

Acids

Keywords

Arenediazonium tosylate salt
Halogenation
Solvent-free grinding

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

Cite this

Moon, M. E., Choi, Y., Lee, Y. M., Vajpayee, V., Trusova, M., Filimonov, V. D., & Chi, K. W. (2010). An expeditious and environmentally benign preparation of aryl halides from aryl amines by solvent-free grinding. Tetrahedron Letters, 51(51), 6769-6771. https://doi.org/10.1016/j.tetlet.2010.10.099

An expeditious and environmentally benign preparation of aryl halides from aryl amines by solvent-free grinding. / Moon, Mi Eun; Choi, Younghwa; Lee, Young Min; Vajpayee, Vaishali; Trusova, Marina ; Filimonov, Victor D.; Chi, Ki Whan.

In: Tetrahedron Letters, Vol. 51, No. 51, 22.12.2010, p. 6769-6771.

Research output: Contribution to journal › Article

Moon, ME, Choi, Y, Lee, YM, Vajpayee, V, Trusova, M , Filimonov, VD & Chi, KW 2010, 'An expeditious and environmentally benign preparation of aryl halides from aryl amines by solvent-free grinding', Tetrahedron Letters, vol. 51, no. 51, pp. 6769-6771. https://doi.org/10.1016/j.tetlet.2010.10.099

Moon ME, Choi Y, Lee YM, Vajpayee V, Trusova M , Filimonov VD et al. An expeditious and environmentally benign preparation of aryl halides from aryl amines by solvent-free grinding. Tetrahedron Letters. 2010 Dec 22;51(51):6769-6771. https://doi.org/10.1016/j.tetlet.2010.10.099

Moon, Mi Eun ; Choi, Younghwa ; Lee, Young Min ; Vajpayee, Vaishali ; Trusova, Marina ; Filimonov, Victor D. ; Chi, Ki Whan. / An expeditious and environmentally benign preparation of aryl halides from aryl amines by solvent-free grinding. In: Tetrahedron Letters. 2010 ; Vol. 51, No. 51. pp. 6769-6771.

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10.1016/j.tetlet.2010.10.099