Abstract
An efficient solvent-free methodology for conversion of various aryl amines into bromides and chlorides via arenediazonium tosylate salts under grinding conditions is disclosed. This new methodology not only avoids the use of strong acids and expensive reagents for diazotization-halogenation reactions, but also decreases the amount of organic waste from the reaction process.
Original language | English |
---|---|
Pages (from-to) | 6769-6771 |
Number of pages | 3 |
Journal | Tetrahedron Letters |
Volume | 51 |
Issue number | 51 |
DOIs | |
Publication status | Published - 22 Dec 2010 |
Keywords
- Arenediazonium tosylate salt
- Halogenation
- Solvent-free grinding
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry