All-Optical Nanoscale Heating and Thermometry with Resonant Dielectric Nanoparticles for Controllable Drug Release in Living Cells

George P. Zograf, Alexander S. Timin, Albert R. Muslimov, Ivan I. Shishkin, Alexandre Nominé, Jaafar Ghanbaja, Pintu Ghosh, Qiang Li, Mikhail V. Zyuzin, Sergey V. Makarov

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Abstract

All-dielectric nanophotonics becomes a versatile tool for various optical applications, including nanothermometry and optical heating. Its general concept includes excitation of Mie resonances in nonplasmonic nanoparticles. However, the potential of resonant dielectric nanoparticles in drug delivery applications still has not been fully realized. Here, optically resonant dielectric iron oxide nanoparticles (α-Fe2O3 NPs) are employed for remote rupture of microcontainers used as a drug delivery platform. It is theoretically and experimentally demonstrated that α-Fe2O3 NPs have several advantages in light-to-heat energy conversion comparing to previously used materials, such as noble metals and silicon, due to the broader spectral range of efficient optical heating, and in enhancement of thermally sensitive Raman signal. The α-Fe2O3 NPs embedded into the wall of universal drug carriers, polymer capsules, are used to experimentally determine the local temperature of the capsule rupture upon laser irradiation (170 °C). As a proof of principle, the delivery and remote release of anticancer drug vincristine upon lowered laser irradiation (4.0× 104 W cm−2) using polymer capsules modified with the α-Fe2O3 NPs is shown. The biological tests are performed on two primary cell types: i) carcinoma cells, as an example of malignant tumor, and ii) human stem cells, as a model of healthy cells.

Original languageEnglish
Article number1900082
JournalLaser and Photonics Reviews
DOIs
Publication statusAccepted/In press - 1 Jan 2020

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Keywords

  • dielectric nanophotonics
  • drug delivery
  • Mie-resonances
  • optical heating

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Condensed Matter Physics

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