Age-related characteristics of epithelial-muscular interactions in the rat trachea

M. V. Kuskov, L. V. Kapilevich, M. B. Baskakov, M. A. Medvedev

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


The interactions between epithelial and muscular cells of tracheal wall were studied by a mechanographic technique in rats of different ages. The state of the epithelium was assessed using hematoxylin-eosin stained sections. The epithelium-dependent relaxation was found to be most pronounced in 10-12-week-old rats. It was not observed in younger rats probably due to the low sensitivity of guanylate cyclase to activating stimuli. Destructive changes in the respiratory epithelium after 24 weeks of life reduced the amplitude of epithelium-dependent relaxation in old rats.

Original languageEnglish
Pages (from-to)1197-1199
Number of pages3
JournalBulletin of Experimental Biology and Medicine
Issue number6
Publication statusPublished - Dec 1998


  • Age
  • Epithelium
  • Smooth muscles
  • Trachea

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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