Age-Dependent changes of redox ratio in rat brain parts, internal organs and blood plasma

Natalia Andreevna Krivova, Olga Borisovna Zaeva, Irina Vladimirovna Sukhodolo, Ivan Vasilevich Milto, Valeria Aleksandrovna Grigorieva

Research output: Contribution to journalArticle

Abstract

Aging of the body is accompanied by a gradual development of the oxidative stress. However, this process has different rates in various systems of the body; so, it seems interesting to compare the levels of oxidative stress in different systems during aging. The luminol-dependent chemiluminescence method with the Fenton reaction was used to investigate the antioxidant capacity. The light sums of chemiluminescence for antioxidant capacity and free radicals of the oxidized molecules were determined to find the ratio of these sums (redox ratio) in the indicated tissues. Changes in the light sums of chemiluminescence for antioxidant capacity and free radicals in the internal organs generally agree with the commonly accepted ideas on the role of oxidative stress in aging. All the studied parts of the brain showed a substantial increase in the light sums of chemiluminescence for antioxidant capacity and free radicals. A comparison of the level of free radicals and the antioxidant capacity has revealed differences in their ratio in the internal organs, blood plasma and brain parts during aging and different levels of oxidative stress. Results of the comparative study gave grounds to suggest that the brain has some other components with antioxidant capacity, which are absent in the heart, lungs, liver and skeletal muscles. Such components in the brain may be glycan, which possess the antioxidant capacity and are widely represented in the brain parts.

Original languageEnglish
Article numberIPL0571
JournalIndian Journal of Science and Technology
Volume8
Issue number27
DOIs
Publication statusPublished - 2015
Externally publishedYes

Keywords

  • 0Internal organs
  • Aging
  • Antioxidant capacity
  • Brain

ASJC Scopus subject areas

  • General

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