Affibody molecules as targeting vectors for PET imaging

Vladimir Tolmachev, Anna Orlova

Research output: Contribution to journalReview articlepeer-review

5 Citations (Scopus)

Abstract

Affibody molecules are small (58 amino acids) engineered scaffold proteins that can be selected to bind to a large variety of proteins with a high affinity. Their small size and high affinity make them attractive as targeting vectors for molecular imaging. High-affinity affibody binders have been selected for several cancer-associated molecular targets. Preclinical studies have shown that radiolabeled affibody molecules can provide highly specific and sensitive imaging on the day of injection; however, for a few targets, imaging on the next day further increased the imaging sensitivity. A phase I/II clinical trial showed that68Ga-labeled affibody molecules permit an accurate and specific measurement of HER2 expression in breast cancer metastases. This paper provides an overview of the factors influencing the biodistribution and targeting properties of affibody molecules and the chemistry of their labeling using positron emitters.

Original languageEnglish
Article number651
JournalCancers
Volume12
Issue number3
DOIs
Publication statusPublished - Mar 2020

Keywords

  • Affibody molecules
  • EGFR
  • HER2
  • Molecular imaging
  • PET
  • Radiolabeling

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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