Adaptation of myocardium to ischemia. The early phase of ischemic preconditioning

L. N. Maslov, Yu B. Lishmanov, N. V. Solenkova

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

It has been systematized modem data on the early phase of ischemic preconditioning and cardiac resistance to pathogenic action of ischemia and reperfusion. It has been performed an analysis published works on the important role of alteration of myocardium energy metabolism in the development of adaptation resistance of the heart to ischemia. It has been shown that adenosine, bradykinin and opioid peptides and also signalling cascade involved phospholipase C and D, protein kinase C, tyrosine kinase and mitochondrial ATP-sensitive potassium channel play a key role in the mechanism of cardioprotective action of ischemic preconditioning.

Original languageEnglish
Pages (from-to)25-41
Number of pages17
JournalUspekhi Fiziologicheskikh Nauk
Volume37
Issue number3
Publication statusPublished - 2006

Fingerprint

Ischemic Preconditioning
Myocardium
Ischemia
Modems
Phospholipase D
KATP Channels
Opioid Peptides
Type C Phospholipases
Bradykinin
Protein-Tyrosine Kinases
Adenosine
Energy Metabolism
Reperfusion
protein kinase C kinase

Keywords

  • Energy metabolism
  • Intercellular and intracellular signalling
  • Ischemic preconditioning

ASJC Scopus subject areas

  • Physiology
  • Medicine(all)

Cite this

Adaptation of myocardium to ischemia. The early phase of ischemic preconditioning. / Maslov, L. N.; Lishmanov, Yu B.; Solenkova, N. V.

In: Uspekhi Fiziologicheskikh Nauk, Vol. 37, No. 3, 2006, p. 25-41.

Research output: Contribution to journalArticle

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