Activation of δ-opioid receptors increases resistance of isolated heart to ischemia/reperfusion

The role of cAMP and intracellular calcium

Yu B. Lishmanov, L. N. Maslov, T. V. Lasukova, A. A. Platonov, P. Oeltgen

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Activation of cardiac δ-opioid receptors (ORs) by their selective agonist DPDPE (154 nM) increased the resistance of perfused rat heart to ischemia/reperfusion injury. Decreased release of creatine phosphokinase to the perfusate and decreased incidence of arrhythmias were observed during reoxygenation. At the same time, opioidergic decrease in left ventricular developed pressure took place both during the preischemic period and after restoring the coronary circulation. All these effects could be prevented by blocking δ-ORs by naltrindole or inhibition of Ca2+-ATPase of sarcoplasmic reticulum by cyclopiazonic acid. δ-OR agonist DPDPE had no effect on cAMP levels in myocardial tissue during the whole experiment. The obtained data suggest that the antiarrhythmic and cytoprotective effects observed after δ-OR stimulation can be realized through the changes in Ca2+ transport at the level of the sarcoplasmic reticulum.

Original languageEnglish
Pages (from-to)45-51
Number of pages7
JournalBiology Bulletin
Volume32
Issue number1
DOIs
Publication statusPublished - 1 Jan 2005

Fingerprint

narcotics
Opioid Receptors
ischemia
Reperfusion
Ischemia
Chemical activation
heart
D-Penicillamine (2,5)-Enkephalin
Calcium
calcium
receptors
naltrindole
sarcoplasmic reticulum
Sarcoplasmic Reticulum
agonists
cyclopiazonic acid
Coronary Circulation
Ca2-transporting ATPase
Calcium-Transporting ATPases
arrhythmia

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Activation of δ-opioid receptors increases resistance of isolated heart to ischemia/reperfusion : The role of cAMP and intracellular calcium. / Lishmanov, Yu B.; Maslov, L. N.; Lasukova, T. V.; Platonov, A. A.; Oeltgen, P.

In: Biology Bulletin, Vol. 32, No. 1, 01.01.2005, p. 45-51.

Research output: Contribution to journalArticle

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