Acetylenic derivatives of betulonic acid amide as a new type of compounds possessing spasmolytic activity

A. I. Govdi, I. V. Sorokina, D. S. Baev, A. O. Bryzgalov, T. G. Tolstikova, G. A. Tolstikov, S. F. Vasilevsky

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Efficient and versatile synthetic procedures towards novel derivatives of betulonic acid via Mannich reaction, Sonogashira cross-coupling, and copper(i)-catalyzed 1,3-dipolar cyclo-additions were developed. Introduction of secondary amines (Mannich reaction) into betulonic acid amides led to derivatives possessing marked spasmolytic activity, which is not characteristic of the triterpene fragment.

Original languageEnglish
Pages (from-to)1327-1334
Number of pages8
JournalRussian Chemical Bulletin
Volume64
Issue number6
DOIs
Publication statusPublished - 1 Jun 2015
Externally publishedYes

Keywords

  • 1,3-dipolar cycloadditions
  • acetylenes
  • anti-inflammatory activity
  • azides
  • betulonic acid
  • hepatoprotective activity
  • Mannich bases
  • spasmolytic activity
  • triterpenoids

ASJC Scopus subject areas

  • Chemistry(all)

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  • Cite this

    Govdi, A. I., Sorokina, I. V., Baev, D. S., Bryzgalov, A. O., Tolstikova, T. G., Tolstikov, G. A., & Vasilevsky, S. F. (2015). Acetylenic derivatives of betulonic acid amide as a new type of compounds possessing spasmolytic activity. Russian Chemical Bulletin, 64(6), 1327-1334. https://doi.org/10.1007/s11172-015-1013-4