About specificity of the antiarrhythmic effect of κ1-opioid receptor agonists

D. S. Ugdyzhekova, L. N. Maslov, A. V. Krylatov, Yu B. Lishmanov, S. W. Tam

Research output: Contribution to journalArticlepeer-review

Abstract

It is demonstrated that intravenous administration of the κ1-opioid receptor (OR) agonists (-)-trans-(1S,S)-U-50,488 and (+)-trans-(1R,2R)-U-50,488 increases heart tolerance to the arrhythmogenic effect of epinephrine in rats. This antiarrhythmic effect was completely abolished by preliminary κ-OR blocking with norbinaltorphimine. Preliminary administration of of a high-affinity κ1-OR agonist (-)-trans-(1S,S)-U-50,488 significantly reduced the incidence of ventricular arrhythmias upon coronary artery occlusion and reperfusion in vivo. The low-affinity (+)-trans-(1R,2R)-U-50,488 does not show antiarrhythmic activity under ischemia and reperfusion of myocardium. It is concluded that the antiarrhythmic action of κ1-OR agonists in the adrenal, ischemic, and reperfusion arrhythmia models has a receptor-specific character.

Original languageEnglish
Pages (from-to)20
Number of pages1
JournalEksperimental'naya i Klinicheskaya Farmakologiya
Volume64
Issue number4
Publication statusPublished - 2001

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)

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