A study of the antiarrhythmic properties of σ-receptor antagonist DuP 734 during ischemia and perfusion of the heart

Yu B. Lishmanov, L. N. Maslov, A. V. Krylatov, S. A. Afanas'ev, V. Yu Timofeev, P. Gilligan, S. W. Tam

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It has been found that in vivo pretreatment of rats with the σ receptor antagonist DuP 734 (1 mg/kg) resulted in an increase in the heart tolerance to ischemic and reperfusion arrhythmias both in vivo and ex vivo. Administration of DuP 734 (1 mg/liter) directly in the perfusion solution of isolated rat heart 10 min before total ischemia also promoted a decrease in the incidence of reperfusion arrhythmias. The normoxic perfusion of isolated rat heart at a dose of 1 mg/liter had no effect on the action potential. It was concluded that antiarrhythmic effect of DuP 734 might depend on the decrease in the Ca2+ overload but not on K+ and Na+ channel blockade.

Original languageEnglish
Pages (from-to)27
Number of pages1
JournalEksperimental'naya i Klinicheskaya Farmakologiya
Issue number6
Publication statusPublished - 2000


ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)

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