A stepwise huisgen cycloaddition process: Copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes

Vsevolod V. Rostovtsev, Luke G. Green, Valery V. Fokin, K. Barry Sharpless

Research output: Contribution to journal › Article

Abstract

By simply stirring in water, organic azides and terminal alkynes are readily and cleanly converted into 1,4-disubstituted 1,2,3-triazoles through a highly efficient and regioselective copper(I)-catalyzed process (see scheme for an example).

Original language	English
Pages (from-to)	2596-2599
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	41
Issue number	14
DOIs	https://doi.org/10.1002/1521-3773(20020715)41:14<2596::AID-ANIE2596>3.0.CO;2-4
Publication status	Published - 15 Jul 2002
Externally published	Yes

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Keywords

Azides
Copper
Cycloaddition
Homogeneous catalysis
Nitrogen heterocycles

ASJC Scopus subject areas

Chemistry(all)

Cite this

Rostovtsev, V. V., Green, L. G., Fokin, V. V., & Sharpless, K. B. (2002). A stepwise huisgen cycloaddition process: Copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes. Angewandte Chemie - International Edition, 41(14), 2596-2599. https://doi.org/10.1002/1521-3773(20020715)41:14<2596::AID-ANIE2596>3.0.CO;2-4

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AU - Sharpless, K. Barry

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Access to Document

10.1002/1521-3773(20020715)41:14<2596::AID-ANIE2596>3.0.CO;2-4