A stepwise huisgen cycloaddition process

Copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes

Vsevolod V. Rostovtsev, Luke G. Green, Valery V. Fokin, K. Barry Sharpless

Research output: Contribution to journalArticle

8076 Citations (Scopus)

Abstract

By simply stirring in water, organic azides and terminal alkynes are readily and cleanly converted into 1,4-disubstituted 1,2,3-triazoles through a highly efficient and regioselective copper(I)-catalyzed process (see scheme for an example).

Original languageEnglish
Pages (from-to)2596-2599
Number of pages4
JournalAngewandte Chemie - International Edition
Volume41
Issue number14
DOIs
Publication statusPublished - 15 Jul 2002
Externally publishedYes

Fingerprint

Triazoles
Alkynes
Azides
Cycloaddition
Copper
Water

Keywords

  • Azides
  • Copper
  • Cycloaddition
  • Homogeneous catalysis
  • Nitrogen heterocycles

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

A stepwise huisgen cycloaddition process : Copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes. / Rostovtsev, Vsevolod V.; Green, Luke G.; Fokin, Valery V.; Sharpless, K. Barry.

In: Angewandte Chemie - International Edition, Vol. 41, No. 14, 15.07.2002, p. 2596-2599.

Research output: Contribution to journalArticle

Rostovtsev, Vsevolod V. ; Green, Luke G. ; Fokin, Valery V. ; Sharpless, K. Barry. / A stepwise huisgen cycloaddition process : Copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes. In: Angewandte Chemie - International Edition. 2002 ; Vol. 41, No. 14. pp. 2596-2599.
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