A simple protocol for the synthesis of α-substituted phosphonates

Xing Wang, Yuan Cai, Jian Chen, Francis Walter Cornelius Verpoort

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

An efficient, easy-to-handle, and mild substitution reaction approach has been developed for the synthesis of phosphonate derivatives, which are very important in the field of industrial, agricultural, and medicinal chemistry. A large number of nucleophiles, including arylamines, alkylamines, heteroarylamines, primary amines and secondary amines, sulfides, and carbides were attempted to react with α-tosyloxyphosphonate 1. The reaction proceeded under catalyst-free and neat conditions and the corresponding phosphonates 2 were afforded in good yields.

Original languageEnglish
Pages (from-to)1268-1273
Number of pages6
JournalPhosphorus, Sulfur and Silicon and the Related Elements
Volume191
Issue number9
DOIs
Publication statusPublished - 2016

Fingerprint

Organophosphonates
Amines
Agricultural Chemistry
Nucleophiles
Pharmaceutical Chemistry
Sulfides
Carbides
Substitution reactions
Derivatives
Catalysts

Keywords

  • catalyst-free
  • p-toluenesulfonyl chloride
  • substitution reaction
  • α-substituted phosphonate

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

A simple protocol for the synthesis of α-substituted phosphonates. / Wang, Xing; Cai, Yuan; Chen, Jian; Verpoort, Francis Walter Cornelius.

In: Phosphorus, Sulfur and Silicon and the Related Elements, Vol. 191, No. 9, 2016, p. 1268-1273.

Research output: Contribution to journalArticle

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