Abstract
An efficient, easy-to-handle, and mild substitution reaction approach has been developed for the synthesis of phosphonate derivatives, which are very important in the field of industrial, agricultural, and medicinal chemistry. A large number of nucleophiles, including arylamines, alkylamines, heteroarylamines, primary amines and secondary amines, sulfides, and carbides were attempted to react with α-tosyloxyphosphonate 1. The reaction proceeded under catalyst-free and neat conditions and the corresponding phosphonates 2 were afforded in good yields.
| Original language | English |
|---|---|
| Pages (from-to) | 1268-1273 |
| Number of pages | 6 |
| Journal | Phosphorus, Sulfur and Silicon and the Related Elements |
| Volume | 191 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 2016 |
Keywords
- catalyst-free
- p-toluenesulfonyl chloride
- substitution reaction
- α-substituted phosphonate
ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry
- Inorganic Chemistry
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Cite this
Wang, X., Cai, Y., Chen, J., & Verpoort, FWC. (2016). A simple protocol for the synthesis of α-substituted phosphonates. Phosphorus, Sulfur and Silicon and the Related Elements, 191(9), 1268-1273. https://doi.org/10.1080/10426507.2016.1167056