A simple protocol for the synthesis of α-substituted phosphonates

Xing Wang, Yuan Cai, Jian Chen, Francis Walter Cornelius Verpoort

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


An efficient, easy-to-handle, and mild substitution reaction approach has been developed for the synthesis of phosphonate derivatives, which are very important in the field of industrial, agricultural, and medicinal chemistry. A large number of nucleophiles, including arylamines, alkylamines, heteroarylamines, primary amines and secondary amines, sulfides, and carbides were attempted to react with α-tosyloxyphosphonate 1. The reaction proceeded under catalyst-free and neat conditions and the corresponding phosphonates 2 were afforded in good yields.

Original languageEnglish
Pages (from-to)1268-1273
Number of pages6
JournalPhosphorus, Sulfur and Silicon and the Related Elements
Issue number9
Publication statusPublished - 2016


  • catalyst-free
  • p-toluenesulfonyl chloride
  • substitution reaction
  • α-substituted phosphonate

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Inorganic Chemistry

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