A simple protocol for the synthesis of α-substituted phosphonates

Xing Wang, Yuan Cai, Jian Chen, Francis Walter Cornelius Verpoort

Research School of Chemistry & Applied Biomedical Sciences

Research output: Contribution to journal › Article

Abstract

An efficient, easy-to-handle, and mild substitution reaction approach has been developed for the synthesis of phosphonate derivatives, which are very important in the field of industrial, agricultural, and medicinal chemistry. A large number of nucleophiles, including arylamines, alkylamines, heteroarylamines, primary amines and secondary amines, sulfides, and carbides were attempted to react with α-tosyloxyphosphonate 1. The reaction proceeded under catalyst-free and neat conditions and the corresponding phosphonates 2 were afforded in good yields.

Original language	English
Pages (from-to)	1268-1273
Number of pages	6
Journal	Phosphorus, Sulfur and Silicon and the Related Elements
Volume	191
Issue number	9
DOIs	https://doi.org/10.1080/10426507.2016.1167056
Publication status	Published - 2016

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Keywords

catalyst-free
p-toluenesulfonyl chloride
substitution reaction
α-substituted phosphonate

ASJC Scopus subject areas

Biochemistry
Organic Chemistry
Inorganic Chemistry

Cite this

Wang, X., Cai, Y., Chen, J., & Verpoort, FWC. (2016). A simple protocol for the synthesis of α-substituted phosphonates. Phosphorus, Sulfur and Silicon and the Related Elements, 191(9), 1268-1273. https://doi.org/10.1080/10426507.2016.1167056

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Access to Document

10.1080/10426507.2016.1167056