Abstract
An efficient, easy-to-handle, and mild substitution reaction approach has been developed for the synthesis of phosphonate derivatives, which are very important in the field of industrial, agricultural, and medicinal chemistry. A large number of nucleophiles, including arylamines, alkylamines, heteroarylamines, primary amines and secondary amines, sulfides, and carbides were attempted to react with α-tosyloxyphosphonate 1. The reaction proceeded under catalyst-free and neat conditions and the corresponding phosphonates 2 were afforded in good yields.
| Original language | English |
|---|---|
| Pages (from-to) | 1268-1273 |
| Number of pages | 6 |
| Journal | Phosphorus, Sulfur and Silicon and the Related Elements |
| Volume | 191 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 2016 |
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Keywords
- catalyst-free
- p-toluenesulfonyl chloride
- substitution reaction
- α-substituted phosphonate
ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry
- Inorganic Chemistry
Cite this
A simple protocol for the synthesis of α-substituted phosphonates. / Wang, Xing; Cai, Yuan; Chen, Jian; Verpoort, Francis Walter Cornelius.
In: Phosphorus, Sulfur and Silicon and the Related Elements, Vol. 191, No. 9, 2016, p. 1268-1273.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A simple protocol for the synthesis of α-substituted phosphonates
AU - Wang, Xing
AU - Cai, Yuan
AU - Chen, Jian
AU - Verpoort, Francis Walter Cornelius
PY - 2016
Y1 - 2016
N2 - An efficient, easy-to-handle, and mild substitution reaction approach has been developed for the synthesis of phosphonate derivatives, which are very important in the field of industrial, agricultural, and medicinal chemistry. A large number of nucleophiles, including arylamines, alkylamines, heteroarylamines, primary amines and secondary amines, sulfides, and carbides were attempted to react with α-tosyloxyphosphonate 1. The reaction proceeded under catalyst-free and neat conditions and the corresponding phosphonates 2 were afforded in good yields.
AB - An efficient, easy-to-handle, and mild substitution reaction approach has been developed for the synthesis of phosphonate derivatives, which are very important in the field of industrial, agricultural, and medicinal chemistry. A large number of nucleophiles, including arylamines, alkylamines, heteroarylamines, primary amines and secondary amines, sulfides, and carbides were attempted to react with α-tosyloxyphosphonate 1. The reaction proceeded under catalyst-free and neat conditions and the corresponding phosphonates 2 were afforded in good yields.
KW - catalyst-free
KW - p-toluenesulfonyl chloride
KW - substitution reaction
KW - α-substituted phosphonate
UR - http://www.scopus.com/inward/record.url?scp=84978525726&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84978525726&partnerID=8YFLogxK
U2 - 10.1080/10426507.2016.1167056
DO - 10.1080/10426507.2016.1167056
M3 - Article
VL - 191
SP - 1268
EP - 1273
JO - Phosphorus, Sulfur and Silicon and the Related Elements
JF - Phosphorus, Sulfur and Silicon and the Related Elements
SN - 1042-6507
IS - 9
ER -