Detailed preclinical study of the safety of the new antiviral agent iodantipyrine was conducted. In LD50 parameters it was found to be related to moderately toxic drugs. Long-term administration in doses of 50, 100, and 250 mg/kg did not cause any essential functional and structural disorders in the organs and systems of rats and dogs. Iodantipyrine does not possess mutagenic and allergenic properties and does not affect the reproductive function.
|Translated title of the contribution||A preclinical trial of iodoantipyrine safety|
|Number of pages||3|
|Journal||Eksperimental'naia i klinicheskaia farmakologiia|
|Publication status||Published - Mar 1998|
ASJC Scopus subject areas
- Pharmacology, Toxicology and Pharmaceutics(all)