A one-pot synthesis of 1-arylalka-1,3-diynes by sequential acetylene zipper and Sonogashira reactions

Irina A. Balova, Svetlana N. Morozkina, David W. Knight, Sergei F. Vasilevsky

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

1,3-Diynes, formed in situ by base-induced acetylene zipper reactions, following anion quenching with water, undergo smooth Sonogashira-type couplings with functionalized aryl iodides, to give good overall yields of 1-arylalka-1,3-diynes.

Original languageEnglish
Pages (from-to)107-109
Number of pages3
JournalTetrahedron Letters
Volume44
Issue number1
DOIs
Publication statusPublished - 1 Jan 2003
Externally publishedYes

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Diynes
Acetylene
Fasteners
Iodides
Anions
Quenching
Water

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

A one-pot synthesis of 1-arylalka-1,3-diynes by sequential acetylene zipper and Sonogashira reactions. / Balova, Irina A.; Morozkina, Svetlana N.; Knight, David W.; Vasilevsky, Sergei F.

In: Tetrahedron Letters, Vol. 44, No. 1, 01.01.2003, p. 107-109.

Research output: Contribution to journalArticle

Balova, Irina A. ; Morozkina, Svetlana N. ; Knight, David W. ; Vasilevsky, Sergei F. / A one-pot synthesis of 1-arylalka-1,3-diynes by sequential acetylene zipper and Sonogashira reactions. In: Tetrahedron Letters. 2003 ; Vol. 44, No. 1. pp. 107-109.
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