A new transformation of aminopyridines upon diazotization in acetonitrile with the formation of N-pyridinylacetamides

A. A. Chudinov, R. S. Dovbnya, E. A. Krasnokutskaya, V. D. Ogorodnikov, I. L. Filimonova

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Diazotization of aminopyridines upon treatment with NaNO2 and H3PO4 in acetonitrile led to the formation of N-pyridinylacetamides. This reaction constitutes a convenient and general preparative method for the synthesis of 2-, 3-, and 4-N-pyridinylacetamides under mild conditions in good yields. The in situ oxidation of the thus obtained N-pyridinylacetamides with hydrogen peroxide gave good yields of pyridinylacetamide N-oxides.

Original languageEnglish
Pages (from-to)2312-2314
Number of pages3
JournalRussian Chemical Bulletin
Volume65
Issue number9
DOIs
Publication statusPublished - 1 Sep 2016

Keywords

  • aminopyridines
  • diazotization
  • N-pyridinylacetamides
  • oxidation

ASJC Scopus subject areas

  • Chemistry(all)

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