Abstract
A new single-stage synthesis of betulin phenylcarbamates is suggested that uses 1-phenylurea as a reagent for betulin O-carbamoylation. A chemoselectivity of hydroxyl-groups in carbamoylation of betulin with 1-phenylurea appeared to occur. Synthesized nitrogen-containing betulin derivatives–phenylcarbamates are valuable as bioactive substances.
Original language | English |
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Pages (from-to) | 1162-1166 |
Number of pages | 5 |
Journal | Journal of Asian Natural Products Research |
Volume | 20 |
Issue number | 12 |
DOIs | |
Publication status | Published - 2 Dec 2018 |
Keywords
- 1-phenylurea
- betulin
- O-carbamoylation
- Pentacyclic triterpenoids
- phenylcarbamates
- phenylisocyanate
ASJC Scopus subject areas
- Analytical Chemistry
- Molecular Medicine
- Pharmacology
- Pharmaceutical Science
- Drug Discovery
- Complementary and alternative medicine
- Organic Chemistry