A new single-stage method for obtaining of betulin phenylcarbamates

A. Elena Mamaeva, S. Saltanat Kaliyeva, A. Abdigali Bakibaev, K. Auezkhan Tashenov, E. Yenglik Nurpeiis

Research output: Contribution to journalArticlepeer-review


A new single-stage synthesis of betulin phenylcarbamates is suggested that uses 1-phenylurea as a reagent for betulin O-carbamoylation. A chemoselectivity of hydroxyl-groups in carbamoylation of betulin with 1-phenylurea appeared to occur. Synthesized nitrogen-containing betulin derivatives–phenylcarbamates are valuable as bioactive substances.

Original languageEnglish
Pages (from-to)1162-1166
Number of pages5
JournalJournal of Asian Natural Products Research
Issue number12
Publication statusPublished - 2 Dec 2018


  • 1-phenylurea
  • betulin
  • O-carbamoylation
  • Pentacyclic triterpenoids
  • phenylcarbamates
  • phenylisocyanate

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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