A new single-stage method for obtaining of betulin phenylcarbamates

Abstract

A new single-stage synthesis of betulin phenylcarbamates is suggested that uses 1-phenylurea as a reagent for betulin O-carbamoylation. A chemoselectivity of hydroxyl-groups in carbamoylation of betulin with 1-phenylurea appeared to occur. Synthesized nitrogen-containing betulin derivatives–phenylcarbamates are valuable as bioactive substances.

Original language	English
Pages (from-to)	1162-1166
Number of pages	5
Journal	Journal of Asian Natural Products Research
Volume	20
Issue number	12
DOIs	https://doi.org/10.1080/10286020.2017.1382480
Publication status	Published - 2 Dec 2018

Keywords

1-phenylurea
betulin
O-carbamoylation
Pentacyclic triterpenoids
phenylcarbamates
phenylisocyanate

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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title = "A new single-stage method for obtaining of betulin phenylcarbamates",

abstract = "A new single-stage synthesis of betulin phenylcarbamates is suggested that uses 1-phenylurea as a reagent for betulin O-carbamoylation. A chemoselectivity of hydroxyl-groups in carbamoylation of betulin with 1-phenylurea appeared to occur. Synthesized nitrogen-containing betulin derivatives–phenylcarbamates are valuable as bioactive substances.",

keywords = "1-phenylurea, betulin, O-carbamoylation, Pentacyclic triterpenoids, phenylcarbamates, phenylisocyanate",

author = "Mamaeva, {A. Elena} and Kaliyeva, {S. Saltanat} and Bakibaev, {A. Abdigali} and Tashenov, {K. Auezkhan} and Nurpeiis, {E. Yenglik}",

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T1 - A new single-stage method for obtaining of betulin phenylcarbamates

AU - Mamaeva, A. Elena

AU - Kaliyeva, S. Saltanat

AU - Bakibaev, A. Abdigali

AU - Tashenov, K. Auezkhan

AU - Nurpeiis, E. Yenglik

PY - 2018/12/2

Y1 - 2018/12/2

N2 - A new single-stage synthesis of betulin phenylcarbamates is suggested that uses 1-phenylurea as a reagent for betulin O-carbamoylation. A chemoselectivity of hydroxyl-groups in carbamoylation of betulin with 1-phenylurea appeared to occur. Synthesized nitrogen-containing betulin derivatives–phenylcarbamates are valuable as bioactive substances.

AB - A new single-stage synthesis of betulin phenylcarbamates is suggested that uses 1-phenylurea as a reagent for betulin O-carbamoylation. A chemoselectivity of hydroxyl-groups in carbamoylation of betulin with 1-phenylurea appeared to occur. Synthesized nitrogen-containing betulin derivatives–phenylcarbamates are valuable as bioactive substances.

KW - 1-phenylurea

KW - betulin

KW - O-carbamoylation

KW - Pentacyclic triterpenoids

KW - phenylcarbamates

KW - phenylisocyanate

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