Abstract
The diazotization of a series of N -oxides of aminopyridines and aminoquinolines under the action of sodium nitrite in the presence of KI and p -TsOH in water at room temperature leads to the formation of the corresponding N -oxides of iodopyridines and iodoquinolines in high yields. The method has a general character and can be used for the preparation of 3-, 2-, and 4- N -oxides of iodopyridines.
| Original language | English |
|---|---|
| Pages (from-to) | 1368-1372 |
| Number of pages | 5 |
| Journal | Synthesis (Germany) |
| Volume | 50 |
| Issue number | 6 |
| DOIs | |
| Publication status | Accepted/In press - 13 Dec 2017 |
Keywords
- diazo compounds
- halogenation
- iodine
- pyridines
- quinolines
ASJC Scopus subject areas
- Catalysis
- Organic Chemistry
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Cite this
Krasnokutskaya, E. A., Chudinov, A. A., & Filimonov, V. D. (Accepted/In press). A New, Simple, and General Synthesis of N -Oxides of Iodopyridines and Iodoquinolines via the Diazotization–Iodination of Heterocyclic Amino N -Oxides in the Presence of p -Toluenesulfonic Acid in Water. Synthesis (Germany), 50(6), 1368-1372. https://doi.org/10.1055/s-0036-1591738