A new route to pyrazolo[3,4-c] and [4,3-c]pyridinones via heterocyclization of vic-substituted hydroxamic acids of acetylenylpyrazoles

Elena V. Mshvidobadze, Sergei F. Vasilevsky, Jose Elguero

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We report in this paper the synthesis of 6-substituted pyrazolo[4,3-c] pyridin-4-ones, 6-substituted 5-hydroxypyrazolo[4,3-c]pyridin-6-ones, 5-substituted pyrazolo[3,4-c]pyridin-7-ones and 5-substituted 6-hydroxypyrazolo[3,4-c]pyridin-7-ones by heterocyclization of vic-acetylenylpyrazol-hydroxamic acids under the influence of copper(I) salt in dimethylformamide or with organic bases in butanol or methanol. Graphical Abstract

Original languageEnglish
Pages (from-to)11875-11878
Number of pages4
JournalTetrahedron
Volume60
Issue number51
DOIs
Publication statusPublished - 13 Dec 2004
Externally publishedYes

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Pyridones
Hydroxamic Acids
Dimethylformamide
Butanols
Methanol
Copper
Salts

Keywords

  • Cross-coupling
  • Hetarylacetylenes
  • Heterocyclization
  • Hydroxamic acids
  • Pyrazolopyridines

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

A new route to pyrazolo[3,4-c] and [4,3-c]pyridinones via heterocyclization of vic-substituted hydroxamic acids of acetylenylpyrazoles. / Mshvidobadze, Elena V.; Vasilevsky, Sergei F.; Elguero, Jose.

In: Tetrahedron, Vol. 60, No. 51, 13.12.2004, p. 11875-11878.

Research output: Contribution to journalArticle

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AU - Elguero, Jose

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AB - We report in this paper the synthesis of 6-substituted pyrazolo[4,3-c] pyridin-4-ones, 6-substituted 5-hydroxypyrazolo[4,3-c]pyridin-6-ones, 5-substituted pyrazolo[3,4-c]pyridin-7-ones and 5-substituted 6-hydroxypyrazolo[3,4-c]pyridin-7-ones by heterocyclization of vic-acetylenylpyrazol-hydroxamic acids under the influence of copper(I) salt in dimethylformamide or with organic bases in butanol or methanol. Graphical Abstract

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