A new approach to osmium-catalyzed asymmetric dihydroxylation and aminohydroxylation of olefins

Malin A. Andersson, Robert Epple, Valery V. Fokin, K. Barry Sharpless

Research output: Contribution to journalArticle

83 Citations (Scopus)

Abstract

Simple hydroxyamino acid derivatives act as chiral ligands in osmium-catalyzed dihydroxylation and aminohydroxylation of olefins (see scheme). These are the first examples of asymmetric osmium-catalyzed processes proceeding in the second catalytic cycle with resident ligands on the metal center.

Original languageEnglish
Pages (from-to)472-475
Number of pages4
JournalAngewandte Chemie - International Edition
Volume41
Issue number3
DOIs
Publication statusPublished - 1 Feb 2002
Externally publishedYes

Keywords

  • Alkenes
  • Aminohydroxylation
  • Dihydroxylation
  • Homogeneous catalysis
  • Osmium

ASJC Scopus subject areas

  • Chemistry(all)

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