A molecular dynamic study of layered hydroxide induced depletion of mobile anions within the extracellular medium

Alexey A. Tsukanov, Sergey G. Psakhie

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The strong surface electric charge density of clay mineral host nanolayers enables their use as host-guest nanohybrids in many different areas of application. In particular, layered double hydroxides (LDH) of metals have found applications in medicine. Drug-LDH or gene-LDH nanohybrids are used for targeted delivery of biomedical agents to diseased cells or cancer cells. Fragments of the LDH host nanolayers may remain both within the cell and in the extracellular medium after drug delivery. How these charged nanosheets affect the cell electrostatics is still poorly understood. In the present paper, the idealized case of a single pure Mg2/Al-LDH nanolayer interacting with the extracellular anion environment was investigated to estimate the order of magnitude of a possible shift of the cell membrane equilibrium potential. An approximate dependence of the change in the chloride equilibrium membrane potential on the concentration of pure Mg2/Al-LDH nanosheets was determined.

Original languageEnglish
Title of host publicationAdvanced Materials with Hierarchical Structure for New Technologies and Reliable Structures
PublisherAmerican Institute of Physics Inc.
Volume1683
ISBN (Electronic)9780735413306
DOIs
Publication statusPublished - 27 Oct 2015
EventInternational Conference on Advanced Materials with Hierarchical Structure for New Technologies and Reliable Structures 2015 - Tomsk, Russian Federation
Duration: 21 Sep 201525 Sep 2015

Conference

ConferenceInternational Conference on Advanced Materials with Hierarchical Structure for New Technologies and Reliable Structures 2015
CountryRussian Federation
CityTomsk
Period21.9.1525.9.15

Keywords

  • anion capturing
  • ion transport
  • Layered double hydroxide
  • membrane potential
  • molecular dynamics

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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