A molecular dynamic study of layered hydroxide induced depletion of mobile anions within the extracellular medium

Alexey A. Tsukanov, Sergey G. Psakhie

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The strong surface electric charge density of clay mineral host nanolayers enables their use as host-guest nanohybrids in many different areas of application. In particular, layered double hydroxides (LDH) of metals have found applications in medicine. Drug-LDH or gene-LDH nanohybrids are used for targeted delivery of biomedical agents to diseased cells or cancer cells. Fragments of the LDH host nanolayers may remain both within the cell and in the extracellular medium after drug delivery. How these charged nanosheets affect the cell electrostatics is still poorly understood. In the present paper, the idealized case of a single pure Mg2/Al-LDH nanolayer interacting with the extracellular anion environment was investigated to estimate the order of magnitude of a possible shift of the cell membrane equilibrium potential. An approximate dependence of the change in the chloride equilibrium membrane potential on the concentration of pure Mg2/Al-LDH nanosheets was determined.

Original languageEnglish
Title of host publicationAdvanced Materials with Hierarchical Structure for New Technologies and Reliable Structures
PublisherAmerican Institute of Physics Inc.
Volume1683
ISBN (Electronic)9780735413306
DOIs
Publication statusPublished - 27 Oct 2015
EventInternational Conference on Advanced Materials with Hierarchical Structure for New Technologies and Reliable Structures 2015 - Tomsk, Russian Federation
Duration: 21 Sep 201525 Sep 2015

Conference

ConferenceInternational Conference on Advanced Materials with Hierarchical Structure for New Technologies and Reliable Structures 2015
CountryRussian Federation
CityTomsk
Period21.9.1525.9.15

Fingerprint

hydroxides
depletion
molecular dynamics
anions
delivery
drugs
cells
electric charge
medicine
genes
clays
cancer
chlorides
minerals
fragments
electrostatics
membranes
shift
estimates
metals

Keywords

  • anion capturing
  • ion transport
  • Layered double hydroxide
  • membrane potential
  • molecular dynamics

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Tsukanov, A. A., & Psakhie, S. G. (2015). A molecular dynamic study of layered hydroxide induced depletion of mobile anions within the extracellular medium. In Advanced Materials with Hierarchical Structure for New Technologies and Reliable Structures (Vol. 1683). [020232] American Institute of Physics Inc.. https://doi.org/10.1063/1.4932922

A molecular dynamic study of layered hydroxide induced depletion of mobile anions within the extracellular medium. / Tsukanov, Alexey A.; Psakhie, Sergey G.

Advanced Materials with Hierarchical Structure for New Technologies and Reliable Structures. Vol. 1683 American Institute of Physics Inc., 2015. 020232.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Tsukanov, AA & Psakhie, SG 2015, A molecular dynamic study of layered hydroxide induced depletion of mobile anions within the extracellular medium. in Advanced Materials with Hierarchical Structure for New Technologies and Reliable Structures. vol. 1683, 020232, American Institute of Physics Inc., International Conference on Advanced Materials with Hierarchical Structure for New Technologies and Reliable Structures 2015, Tomsk, Russian Federation, 21.9.15. https://doi.org/10.1063/1.4932922
Tsukanov AA, Psakhie SG. A molecular dynamic study of layered hydroxide induced depletion of mobile anions within the extracellular medium. In Advanced Materials with Hierarchical Structure for New Technologies and Reliable Structures. Vol. 1683. American Institute of Physics Inc. 2015. 020232 https://doi.org/10.1063/1.4932922
Tsukanov, Alexey A. ; Psakhie, Sergey G. / A molecular dynamic study of layered hydroxide induced depletion of mobile anions within the extracellular medium. Advanced Materials with Hierarchical Structure for New Technologies and Reliable Structures. Vol. 1683 American Institute of Physics Inc., 2015.
@inproceedings{d937901c8cde40f7a41844263a2b7c95,
title = "A molecular dynamic study of layered hydroxide induced depletion of mobile anions within the extracellular medium",
abstract = "The strong surface electric charge density of clay mineral host nanolayers enables their use as host-guest nanohybrids in many different areas of application. In particular, layered double hydroxides (LDH) of metals have found applications in medicine. Drug-LDH or gene-LDH nanohybrids are used for targeted delivery of biomedical agents to diseased cells or cancer cells. Fragments of the LDH host nanolayers may remain both within the cell and in the extracellular medium after drug delivery. How these charged nanosheets affect the cell electrostatics is still poorly understood. In the present paper, the idealized case of a single pure Mg2/Al-LDH nanolayer interacting with the extracellular anion environment was investigated to estimate the order of magnitude of a possible shift of the cell membrane equilibrium potential. An approximate dependence of the change in the chloride equilibrium membrane potential on the concentration of pure Mg2/Al-LDH nanosheets was determined.",
keywords = "anion capturing, ion transport, Layered double hydroxide, membrane potential, molecular dynamics",
author = "Tsukanov, {Alexey A.} and Psakhie, {Sergey G.}",
year = "2015",
month = "10",
day = "27",
doi = "10.1063/1.4932922",
language = "English",
volume = "1683",
booktitle = "Advanced Materials with Hierarchical Structure for New Technologies and Reliable Structures",
publisher = "American Institute of Physics Inc.",

}

TY - GEN

T1 - A molecular dynamic study of layered hydroxide induced depletion of mobile anions within the extracellular medium

AU - Tsukanov, Alexey A.

AU - Psakhie, Sergey G.

PY - 2015/10/27

Y1 - 2015/10/27

N2 - The strong surface electric charge density of clay mineral host nanolayers enables their use as host-guest nanohybrids in many different areas of application. In particular, layered double hydroxides (LDH) of metals have found applications in medicine. Drug-LDH or gene-LDH nanohybrids are used for targeted delivery of biomedical agents to diseased cells or cancer cells. Fragments of the LDH host nanolayers may remain both within the cell and in the extracellular medium after drug delivery. How these charged nanosheets affect the cell electrostatics is still poorly understood. In the present paper, the idealized case of a single pure Mg2/Al-LDH nanolayer interacting with the extracellular anion environment was investigated to estimate the order of magnitude of a possible shift of the cell membrane equilibrium potential. An approximate dependence of the change in the chloride equilibrium membrane potential on the concentration of pure Mg2/Al-LDH nanosheets was determined.

AB - The strong surface electric charge density of clay mineral host nanolayers enables their use as host-guest nanohybrids in many different areas of application. In particular, layered double hydroxides (LDH) of metals have found applications in medicine. Drug-LDH or gene-LDH nanohybrids are used for targeted delivery of biomedical agents to diseased cells or cancer cells. Fragments of the LDH host nanolayers may remain both within the cell and in the extracellular medium after drug delivery. How these charged nanosheets affect the cell electrostatics is still poorly understood. In the present paper, the idealized case of a single pure Mg2/Al-LDH nanolayer interacting with the extracellular anion environment was investigated to estimate the order of magnitude of a possible shift of the cell membrane equilibrium potential. An approximate dependence of the change in the chloride equilibrium membrane potential on the concentration of pure Mg2/Al-LDH nanosheets was determined.

KW - anion capturing

KW - ion transport

KW - Layered double hydroxide

KW - membrane potential

KW - molecular dynamics

UR - http://www.scopus.com/inward/record.url?scp=84984550364&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84984550364&partnerID=8YFLogxK

U2 - 10.1063/1.4932922

DO - 10.1063/1.4932922

M3 - Conference contribution

AN - SCOPUS:84984550364

VL - 1683

BT - Advanced Materials with Hierarchical Structure for New Technologies and Reliable Structures

PB - American Institute of Physics Inc.

ER -