A molecular dynamic study of charged nanofilm interaction with negative lipid bilayer

Alexey A. Tsukanov, Sergey G. Psakhie

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Citations (Scopus)

Abstract

Hydrophobic and functionalized nanoparticles of different sizes and shapes have a various biomedical application, in particular anticancer therapy. It is known that charged nanoparticles may bind lipids and membrane proteins as well as cause lipid bilayer disruption. We have performed preliminary molecular dynamic simulations to investigate the effect of positively charged synthetic nanofilm, imitating a fragment of the two-dimensional folded AlOOH structure, on the POPE/POPG lipid membrane. It has been shown that the synthetic nanofilm with frozen coordinates tightens the membrane and binds lipid headgroups. Furthermore, the presence of the positively charged nanofilm perturbs the cation concentration in the near-surface membrane region.

Original languageEnglish
Title of host publicationAIP Conference Proceedings
PublisherAmerican Institute of Physics Inc.
Pages639-642
Number of pages4
Volume1623
ISBN (Electronic)9780735412606
DOIs
Publication statusPublished - 1 Jan 2014
EventInternational Conference on Physical Mesomechanics of Multilevel Systems 2014 - Tomsk, Russian Federation
Duration: 3 Sep 20145 Sep 2014

Conference

ConferenceInternational Conference on Physical Mesomechanics of Multilevel Systems 2014
CountryRussian Federation
CityTomsk
Period3.9.145.9.14

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Keywords

  • Aluminum oxyhydroxide
  • Antitumor therapeutics
  • Cancer
  • Charged nanofilm
  • Ion transport
  • Lipid membrane
  • Molecular dynamics

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Tsukanov, A. A., & Psakhie, S. G. (2014). A molecular dynamic study of charged nanofilm interaction with negative lipid bilayer. In AIP Conference Proceedings (Vol. 1623, pp. 639-642). American Institute of Physics Inc.. https://doi.org/10.1063/1.4899026