A microwave-assisted click chemistry synthesis of 1,4-disubstituted 1,2,3-triazoles via a copper(I)-catalyzed three-component reaction

Prasad Appukkuttan, Wim Dehaen, Valery V. Fokin, Erik Van Der Eycken

Research output: Contribution to journalArticle

529 Citations (Scopus)

Abstract

(Chemical Equation Presented) A microwave-assisted three-component reaction was used to prepare a series of 1,4-disubstituted-1,2,3-triazoles from corresponding alkyl halides, sodium azide, and alkynes. This procedure eliminates the need to handle organic azides, as they are generated in situ, making this already powerful click process even more user-friendly and safe.

Original languageEnglish
Pages (from-to)4223-4225
Number of pages3
JournalOrganic Letters
Volume6
Issue number23
Publication statusPublished - 11 Nov 2004
Externally publishedYes

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azides (organic)
synthesis (chemistry)
Click Chemistry
sodium azides
Sodium Azide
Triazoles
Alkynes
Azides
alkynes
Microwaves
halides
Copper
microwaves
copper

ASJC Scopus subject areas

  • Molecular Medicine

Cite this

A microwave-assisted click chemistry synthesis of 1,4-disubstituted 1,2,3-triazoles via a copper(I)-catalyzed three-component reaction. / Appukkuttan, Prasad; Dehaen, Wim; Fokin, Valery V.; Van Der Eycken, Erik.

In: Organic Letters, Vol. 6, No. 23, 11.11.2004, p. 4223-4225.

Research output: Contribution to journalArticle

Appukkuttan, Prasad ; Dehaen, Wim ; Fokin, Valery V. ; Van Der Eycken, Erik. / A microwave-assisted click chemistry synthesis of 1,4-disubstituted 1,2,3-triazoles via a copper(I)-catalyzed three-component reaction. In: Organic Letters. 2004 ; Vol. 6, No. 23. pp. 4223-4225.
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