A microwave-assisted click chemistry synthesis of 1,4-disubstituted 1,2,3-triazoles via a copper(I)-catalyzed three-component reaction

Prasad Appukkuttan, Wim Dehaen, Valery V. Fokin, Erik Van Der Eycken

Research output: Contribution to journalArticlepeer-review

548 Citations (Scopus)

Abstract

(Chemical Equation Presented) A microwave-assisted three-component reaction was used to prepare a series of 1,4-disubstituted-1,2,3-triazoles from corresponding alkyl halides, sodium azide, and alkynes. This procedure eliminates the need to handle organic azides, as they are generated in situ, making this already powerful click process even more user-friendly and safe.

Original languageEnglish
Pages (from-to)4223-4225
Number of pages3
JournalOrganic Letters
Volume6
Issue number23
Publication statusPublished - 11 Nov 2004
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Medicine

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