A method for the efficient degradation of melphalan into nonmutagenic products

J. Barek, M. Castegnaro, C. Malaveille, I. Brouet, J. Zima

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


A new chemical method has been developed for the destruction of an antineoplastic agent melphalane in laboratory waste, based on its oxidation by potassium permanganate in sodium hydroxide medium. To monitor the efficiency of destruction, analytical methods based on UV spectrophotometry, differential pulse voltammetry on a glassy carbon rotating disk electrode, and HPLC coupled with UV spectrophotometry have been developed. It has been demonstrated that the proposed method of destruction is highly efficient (more than 99.8% destruction) and the corresponding degradation products were found to be nonmutagenic to Salmonella typhimurium strains TA98, TA100, and TA1535, in both the presence and the absence of a rat liver S9 activation system.

Original languageEnglish
Pages (from-to)192-197
Number of pages6
JournalMicrochemical Journal
Issue number2
Publication statusPublished - 1 Jan 1987
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy

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