A method for the efficient degradation of melphalan into nonmutagenic products

Abstract

A new chemical method has been developed for the destruction of an antineoplastic agent melphalane in laboratory waste, based on its oxidation by potassium permanganate in sodium hydroxide medium. To monitor the efficiency of destruction, analytical methods based on UV spectrophotometry, differential pulse voltammetry on a glassy carbon rotating disk electrode, and HPLC coupled with UV spectrophotometry have been developed. It has been demonstrated that the proposed method of destruction is highly efficient (more than 99.8% destruction) and the corresponding degradation products were found to be nonmutagenic to Salmonella typhimurium strains TA98, TA100, and TA1535, in both the presence and the absence of a rat liver S9 activation system.

Original language	English
Pages (from-to)	192-197
Number of pages	6
Journal	Microchemical Journal
Volume	36
Issue number	2
DOIs	https://doi.org/10.1016/0026-265X(87)90153-6
Publication status	Published - 1 Jan 1987
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
Spectroscopy

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10.1016/0026-265X(87)90153-6

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@article{276c807f8c634edba6c7b1b2698f43ab,

title = "A method for the efficient degradation of melphalan into nonmutagenic products",

abstract = "A new chemical method has been developed for the destruction of an antineoplastic agent melphalane in laboratory waste, based on its oxidation by potassium permanganate in sodium hydroxide medium. To monitor the efficiency of destruction, analytical methods based on UV spectrophotometry, differential pulse voltammetry on a glassy carbon rotating disk electrode, and HPLC coupled with UV spectrophotometry have been developed. It has been demonstrated that the proposed method of destruction is highly efficient (more than 99.8% destruction) and the corresponding degradation products were found to be nonmutagenic to Salmonella typhimurium strains TA98, TA100, and TA1535, in both the presence and the absence of a rat liver S9 activation system.",

author = "J. Barek and M. Castegnaro and C. Malaveille and I. Brouet and J. Zima",

year = "1987",

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doi = "10.1016/0026-265X(87)90153-6",

language = "English",

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journal = "Microchemical Journal",

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T1 - A method for the efficient degradation of melphalan into nonmutagenic products

AU - Barek, J.

AU - Castegnaro, M.

AU - Malaveille, C.

AU - Brouet, I.

AU - Zima, J.

PY - 1987/1/1

Y1 - 1987/1/1

N2 - A new chemical method has been developed for the destruction of an antineoplastic agent melphalane in laboratory waste, based on its oxidation by potassium permanganate in sodium hydroxide medium. To monitor the efficiency of destruction, analytical methods based on UV spectrophotometry, differential pulse voltammetry on a glassy carbon rotating disk electrode, and HPLC coupled with UV spectrophotometry have been developed. It has been demonstrated that the proposed method of destruction is highly efficient (more than 99.8% destruction) and the corresponding degradation products were found to be nonmutagenic to Salmonella typhimurium strains TA98, TA100, and TA1535, in both the presence and the absence of a rat liver S9 activation system.

AB - A new chemical method has been developed for the destruction of an antineoplastic agent melphalane in laboratory waste, based on its oxidation by potassium permanganate in sodium hydroxide medium. To monitor the efficiency of destruction, analytical methods based on UV spectrophotometry, differential pulse voltammetry on a glassy carbon rotating disk electrode, and HPLC coupled with UV spectrophotometry have been developed. It has been demonstrated that the proposed method of destruction is highly efficient (more than 99.8% destruction) and the corresponding degradation products were found to be nonmutagenic to Salmonella typhimurium strains TA98, TA100, and TA1535, in both the presence and the absence of a rat liver S9 activation system.

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