Abstract
A new chemical method has been developed for the destruction of an antineoplastic agent melphalane in laboratory waste, based on its oxidation by potassium permanganate in sodium hydroxide medium. To monitor the efficiency of destruction, analytical methods based on UV spectrophotometry, differential pulse voltammetry on a glassy carbon rotating disk electrode, and HPLC coupled with UV spectrophotometry have been developed. It has been demonstrated that the proposed method of destruction is highly efficient (more than 99.8% destruction) and the corresponding degradation products were found to be nonmutagenic to Salmonella typhimurium strains TA98, TA100, and TA1535, in both the presence and the absence of a rat liver S9 activation system.
| Original language | English |
|---|---|
| Pages (from-to) | 192-197 |
| Number of pages | 6 |
| Journal | Microchemical Journal |
| Volume | 36 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1 Jan 1987 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Analytical Chemistry
- Spectroscopy
Cite this
A method for the efficient degradation of melphalan into nonmutagenic products. / Barek, J.; Castegnaro, M.; Malaveille, C.; Brouet, I.; Zima, J.
In: Microchemical Journal, Vol. 36, No. 2, 01.01.1987, p. 192-197.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A method for the efficient degradation of melphalan into nonmutagenic products
AU - Barek, J.
AU - Castegnaro, M.
AU - Malaveille, C.
AU - Brouet, I.
AU - Zima, J.
PY - 1987/1/1
Y1 - 1987/1/1
N2 - A new chemical method has been developed for the destruction of an antineoplastic agent melphalane in laboratory waste, based on its oxidation by potassium permanganate in sodium hydroxide medium. To monitor the efficiency of destruction, analytical methods based on UV spectrophotometry, differential pulse voltammetry on a glassy carbon rotating disk electrode, and HPLC coupled with UV spectrophotometry have been developed. It has been demonstrated that the proposed method of destruction is highly efficient (more than 99.8% destruction) and the corresponding degradation products were found to be nonmutagenic to Salmonella typhimurium strains TA98, TA100, and TA1535, in both the presence and the absence of a rat liver S9 activation system.
AB - A new chemical method has been developed for the destruction of an antineoplastic agent melphalane in laboratory waste, based on its oxidation by potassium permanganate in sodium hydroxide medium. To monitor the efficiency of destruction, analytical methods based on UV spectrophotometry, differential pulse voltammetry on a glassy carbon rotating disk electrode, and HPLC coupled with UV spectrophotometry have been developed. It has been demonstrated that the proposed method of destruction is highly efficient (more than 99.8% destruction) and the corresponding degradation products were found to be nonmutagenic to Salmonella typhimurium strains TA98, TA100, and TA1535, in both the presence and the absence of a rat liver S9 activation system.
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U2 - 10.1016/0026-265X(87)90153-6
DO - 10.1016/0026-265X(87)90153-6
M3 - Article
VL - 36
SP - 192
EP - 197
JO - Microchemical Journal
JF - Microchemical Journal
SN - 0026-265X
IS - 2
ER -