A fiber distribution model for predicting drug release rates

D. G. Petlin, A. A. Amarah, S. I. Tverdokhlebov, Y. G. Anissimov

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Sustained drug release can be achieved by loading a drug into polymer material. The drug release can then be controlled for potential use in various biomedical applications. A model for drug release from a polymeric fibrous scaffold, which takes into account the distribution of fiber diameters within its structure, is developed here. It is demonstrated that the fiber diameter distribution significantly affects the drug release profile from electrospun scaffolds. The developed model indicates that altering the fiber distribution can be used as an additional tool to achieve an appropriate drug release profile. Using published data, it was demonstrated that an application of the model allows a more precise calculation of the drug diffusion coefficient within the polymer, which is important for predicting drug release rates from fabricated materials.

Original languageEnglish
Pages (from-to)218-225
Number of pages8
JournalJournal of Controlled Release
Volume258
DOIs
Publication statusPublished - 28 Jul 2017

Keywords

  • Controlled drug release
  • Diffusion
  • Drug release
  • Electrospinning
  • Mathematical modeling
  • Nanofiber

ASJC Scopus subject areas

  • Pharmaceutical Science

Fingerprint Dive into the research topics of 'A fiber distribution model for predicting drug release rates'. Together they form a unique fingerprint.

  • Cite this