Abstract
Sustained drug release can be achieved by loading a drug into polymer material. The drug release can then be controlled for potential use in various biomedical applications. A model for drug release from a polymeric fibrous scaffold, which takes into account the distribution of fiber diameters within its structure, is developed here. It is demonstrated that the fiber diameter distribution significantly affects the drug release profile from electrospun scaffolds. The developed model indicates that altering the fiber distribution can be used as an additional tool to achieve an appropriate drug release profile. Using published data, it was demonstrated that an application of the model allows a more precise calculation of the drug diffusion coefficient within the polymer, which is important for predicting drug release rates from fabricated materials.
| Original language | English |
|---|---|
| Pages (from-to) | 218-225 |
| Number of pages | 8 |
| Journal | Journal of Controlled Release |
| Volume | 258 |
| DOIs | |
| Publication status | Published - 28 Jul 2017 |
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Keywords
- Controlled drug release
- Diffusion
- Drug release
- Electrospinning
- Mathematical modeling
- Nanofiber
ASJC Scopus subject areas
- Pharmaceutical Science
Cite this
A fiber distribution model for predicting drug release rates. / Petlin, D. G.; Amarah, A. A.; Tverdokhlebov, S. I.; Anissimov, Y. G.
In: Journal of Controlled Release, Vol. 258, 28.07.2017, p. 218-225.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A fiber distribution model for predicting drug release rates
AU - Petlin, D. G.
AU - Amarah, A. A.
AU - Tverdokhlebov, S. I.
AU - Anissimov, Y. G.
PY - 2017/7/28
Y1 - 2017/7/28
N2 - Sustained drug release can be achieved by loading a drug into polymer material. The drug release can then be controlled for potential use in various biomedical applications. A model for drug release from a polymeric fibrous scaffold, which takes into account the distribution of fiber diameters within its structure, is developed here. It is demonstrated that the fiber diameter distribution significantly affects the drug release profile from electrospun scaffolds. The developed model indicates that altering the fiber distribution can be used as an additional tool to achieve an appropriate drug release profile. Using published data, it was demonstrated that an application of the model allows a more precise calculation of the drug diffusion coefficient within the polymer, which is important for predicting drug release rates from fabricated materials.
AB - Sustained drug release can be achieved by loading a drug into polymer material. The drug release can then be controlled for potential use in various biomedical applications. A model for drug release from a polymeric fibrous scaffold, which takes into account the distribution of fiber diameters within its structure, is developed here. It is demonstrated that the fiber diameter distribution significantly affects the drug release profile from electrospun scaffolds. The developed model indicates that altering the fiber distribution can be used as an additional tool to achieve an appropriate drug release profile. Using published data, it was demonstrated that an application of the model allows a more precise calculation of the drug diffusion coefficient within the polymer, which is important for predicting drug release rates from fabricated materials.
KW - Controlled drug release
KW - Diffusion
KW - Drug release
KW - Electrospinning
KW - Mathematical modeling
KW - Nanofiber
UR - http://www.scopus.com/inward/record.url?scp=85020296840&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85020296840&partnerID=8YFLogxK
U2 - 10.1016/j.jconrel.2017.05.021
DO - 10.1016/j.jconrel.2017.05.021
M3 - Article
VL - 258
SP - 218
EP - 225
JO - Journal of Controlled Release
JF - Journal of Controlled Release
SN - 0168-3659
ER -