4-Iodoantipyrine synthesized by means of solid-state mechanical activation

Abstract

Antipyrine and its benzenesulfonate were iodinated by solid-state mechanical activation (in the absence of solvent) under the action of iodine, iodine chloride, Me₄N⁺ICl₂ ^-, and Et₄N⁺ICl₂ ^- with the formation of 4-iodoantipyrine. The proposed process does not require organic solvents and meets all Green Chemistry demands. The best results were achieved with the use of tetraalkylammonium salts Me₄N⁺ICl₂ ^- and Et₄N⁺ICl₂ ^-.

Original language	English
Pages (from-to)	154-156
Number of pages	3
Journal	Pharmaceutical Chemistry Journal
Volume	41
Issue number	3
DOIs	https://doi.org/10.1007/s11094-007-0034-1
Publication status	Published - Mar 2007

ASJC Scopus subject areas

Molecular Medicine
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1007/s11094-007-0034-1

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title = "4-Iodoantipyrine synthesized by means of solid-state mechanical activation",

abstract = "Antipyrine and its benzenesulfonate were iodinated by solid-state mechanical activation (in the absence of solvent) under the action of iodine, iodine chloride, Me4N+ICl2 -, and Et4N+ICl2 - with the formation of 4-iodoantipyrine. The proposed process does not require organic solvents and meets all Green Chemistry demands. The best results were achieved with the use of tetraalkylammonium salts Me4N+ICl2 - and Et4N+ICl2 -.",

author = "Krasnokutskaya, {E. A.} and Trusova, {M. E.} and Gibert, {N. S.} and Filimonov, {V. D.}",

year = "2007",

month = mar,

doi = "10.1007/s11094-007-0034-1",

language = "English",

volume = "41",

pages = "154--156",

journal = "Pharmaceutical Chemistry Journal",

issn = "0091-150X",

publisher = "Springer New York",

number = "3",

}

TY - JOUR

T1 - 4-Iodoantipyrine synthesized by means of solid-state mechanical activation

AU - Krasnokutskaya, E. A.

AU - Trusova, M. E.

AU - Gibert, N. S.

AU - Filimonov, V. D.

PY - 2007/3

Y1 - 2007/3

N2 - Antipyrine and its benzenesulfonate were iodinated by solid-state mechanical activation (in the absence of solvent) under the action of iodine, iodine chloride, Me4N+ICl2 -, and Et4N+ICl2 - with the formation of 4-iodoantipyrine. The proposed process does not require organic solvents and meets all Green Chemistry demands. The best results were achieved with the use of tetraalkylammonium salts Me4N+ICl2 - and Et4N+ICl2 -.

AB - Antipyrine and its benzenesulfonate were iodinated by solid-state mechanical activation (in the absence of solvent) under the action of iodine, iodine chloride, Me4N+ICl2 -, and Et4N+ICl2 - with the formation of 4-iodoantipyrine. The proposed process does not require organic solvents and meets all Green Chemistry demands. The best results were achieved with the use of tetraalkylammonium salts Me4N+ICl2 - and Et4N+ICl2 -.

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U2 - 10.1007/s11094-007-0034-1

DO - 10.1007/s11094-007-0034-1

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EP - 156

JO - Pharmaceutical Chemistry Journal

JF - Pharmaceutical Chemistry Journal

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