Abstract
Antipyrine and its benzenesulfonate were iodinated by solid-state mechanical activation (in the absence of solvent) under the action of iodine, iodine chloride, Me4N+ICl2 -, and Et4N+ICl2 - with the formation of 4-iodoantipyrine. The proposed process does not require organic solvents and meets all Green Chemistry demands. The best results were achieved with the use of tetraalkylammonium salts Me4N+ICl2 - and Et4N+ICl2 -.
| Original language | English |
|---|---|
| Pages (from-to) | 154-156 |
| Number of pages | 3 |
| Journal | Pharmaceutical Chemistry Journal |
| Volume | 41 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Mar 2007 |
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ASJC Scopus subject areas
- Molecular Medicine
- Pharmacology, Toxicology and Pharmaceutics(all)
Cite this
4-Iodoantipyrine synthesized by means of solid-state mechanical activation. / Krasnokutskaya, E. A.; Trusova, M. E.; Gibert, N. S.; Filimonov, V. D.
In: Pharmaceutical Chemistry Journal, Vol. 41, No. 3, 03.2007, p. 154-156.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - 4-Iodoantipyrine synthesized by means of solid-state mechanical activation
AU - Krasnokutskaya, E. A.
AU - Trusova, M. E.
AU - Gibert, N. S.
AU - Filimonov, V. D.
PY - 2007/3
Y1 - 2007/3
N2 - Antipyrine and its benzenesulfonate were iodinated by solid-state mechanical activation (in the absence of solvent) under the action of iodine, iodine chloride, Me4N+ICl2 -, and Et4N+ICl2 - with the formation of 4-iodoantipyrine. The proposed process does not require organic solvents and meets all Green Chemistry demands. The best results were achieved with the use of tetraalkylammonium salts Me4N+ICl2 - and Et4N+ICl2 -.
AB - Antipyrine and its benzenesulfonate were iodinated by solid-state mechanical activation (in the absence of solvent) under the action of iodine, iodine chloride, Me4N+ICl2 -, and Et4N+ICl2 - with the formation of 4-iodoantipyrine. The proposed process does not require organic solvents and meets all Green Chemistry demands. The best results were achieved with the use of tetraalkylammonium salts Me4N+ICl2 - and Et4N+ICl2 -.
UR - http://www.scopus.com/inward/record.url?scp=35148860205&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=35148860205&partnerID=8YFLogxK
U2 - 10.1007/s11094-007-0034-1
DO - 10.1007/s11094-007-0034-1
M3 - Article
VL - 41
SP - 154
EP - 156
JO - Pharmaceutical Chemistry Journal
JF - Pharmaceutical Chemistry Journal
SN - 0091-150X
IS - 3
ER -