4-Iodoantipyrine synthesized by means of solid-state mechanical activation

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3 Citations (Scopus)


Antipyrine and its benzenesulfonate were iodinated by solid-state mechanical activation (in the absence of solvent) under the action of iodine, iodine chloride, Me4N+ICl2 -, and Et4N+ICl2 - with the formation of 4-iodoantipyrine. The proposed process does not require organic solvents and meets all Green Chemistry demands. The best results were achieved with the use of tetraalkylammonium salts Me4N+ICl2 - and Et4N+ICl2 -.

Original languageEnglish
Pages (from-to)154-156
Number of pages3
JournalPharmaceutical Chemistry Journal
Issue number3
Publication statusPublished - Mar 2007

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)

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