μ-Opioidergic Stimulation of KATP-Channels as an Approach to Prevention of Reperfusion Damage of the Heart in Experiment

L. N. Maslov, Yu B. Lishmanov, T. V. Lasukova, S. V. Tam

Research output: Contribution to journalArticlepeer-review

Abstract

In vivo pretreatment with selective μ-opioid receptor agonist DAMCO (0.1 mg/kg intravenously 15 min before heart isolation) increased tolerance of the isolated perfused rat heart to ischemic (45 min) and reperfusion (60 min) damages in vitro. This prior stimulation of μ-opioid receptors led to significant improvement of postreperfusion contractile function, significant prevention of reoxygenation destruction of cardiac cells and a decrease in the incidence of reperfusion arrhythmias. All these cardioprotective effects of μ-receptor activation were completely eliminated by pretreatment with the opioid receptor antagonist naloxone (0.1 mg/kg intravenously 10 min before DAMGO injection) or by pretreatment with the KATP-channel blocker glibenclamide (0.3 mg/kg intravenously 30 min before DAMGO injection). It is concluded that μ-opioid receptor activation can be an approach to prevent ischemic/reperfusion damage of the heart. Cardioprotective effects of μ-receptor activation can be mediated via KATP-channels.

Original languageEnglish
Pages (from-to)39-45
Number of pages7
JournalKardiologiya
Volume41
Issue number2
Publication statusPublished - 2001

Keywords

  • μ-receptors
  • Ischemia and reperfusion of the heart
  • K-channels

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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